Renal dysfunction by BK virus infection is correlated with activated T cell level in renal transplantation

被引：2
|
作者：
Lee, Ming-Che [1 ]
Lu, Ming-Chi [2 ]
Lai, Ning-Sheng [2 ]
Liu, Su-Chin [3 ]
Yu, Hui-Chun [3 ]
Lin, Teng-Yi [4 ]
Hung, Shueh-Ping [9 ]
Huang, Hsien-Bin [5 ,6 ]
Yin, Wen-Yao [7 ,8 ]
机构：
[1] Buddhist Hualien Tzu Chi Gen Hosp, Dept Surg, Hualien, Taiwan
[2] Buddhist Dalin Tzu Chi Gen Hosp, Dept Rheumatol, Chiayi, Taiwan
[3] Buddhist Dalin Tzu Chi Gen Hosp, Dept Res, Chiayi, Taiwan
[4] Buddhist Tzu Chi Gen Hosp, Dept Lab Med, Hualien, Taiwan
[5] Natl Chung Cheng Univ, Dept Life Sci, Chiayi, Taiwan
[6] Natl Chung Cheng Univ, Inst Mol Biol, Chiayi, Taiwan
[7] Buddhist Dalin Tzu Chi Gen Hosp, Dept Organ Transplantat, Chiayi, Taiwan
[8] Tzu Chi Univ, Hualien, Taiwan
[9] Buddhist Dalin Tzu Chi Gen Hosp, Dept Nursing, Chiayi, Taiwan
来源：
JOURNAL OF SURGICAL RESEARCH | 2013年 / 180卷 / 02期
关键词：
Renal dysfunction; BK virus; Activated T cell; Immunosuppression; POLYOMAVIRUS-ASSOCIATED NEPHROPATHY; RISK-FACTORS; IMMUNOSUPPRESSIVE DRUGS; ALLOGRAFT RECIPIENTS; CLINICAL-COURSE; NATIVE KIDNEYS; NEPHRITIS; CIDOFOVIR; REPLICATION; MANAGEMENT;
D O I：
10.1016/j.jss.2012.04.064
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background: BK virus (BKV) is known to be associated with nephropathy. Here, we investigated the relationships between BKV levels, T-cell activation, and kidney function in kidney transplant recipients. Materials and methods: In renal transplant patients and controls, urine BKV levels were detected by quantitative real-time PCR, and the percentage of activated T lymphocytes in blood was determined by flow cytometry. The correlations between viral load, activated T cell percentage, and renal function were determined. Results: Urine BKV viral loads and the activated T cell percentage were significantly elevated in transplant recipients. Correlational analysis indicated that transplant recipients that had BKV levels of more than 10(6) copies/mL and an activated T lymphocyte percentage of less than 20% were likely to have poor renal function. Conclusions: Urine BKV levels and the percentage of activated T lymphocytes can be used as clinical indices to optimize the dosage of immunosuppressive drugs. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：330 / 336
页数：7
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