Polar Nature of Biomimetic Fluorapatite/Gelatin Composites: A Comparison of Bipolar Objects and the Polar State of Natural Tissue

被引：18

作者：

Burgener, Matthias ^{[1
]}

Putzeys, Tristan ^{[2
]}

Gashti, Mazeyar Parvinzadeh ^{[1
]}

Busch, Susanne ^{[3
]}

Aboulfadl, Hanane ^{[1
]}

Wubbenhorst, Michael ^{[2
]}

Kniep, Ruediger ^{[3
]}

Hulliger, Juerg ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

[2] Katholieke Univ Leuven, Dept Phys & Astron, Soft Matter & Biophys Sect, B-3001 Louvain, Belgium

[3] Max Planck Inst Chem Phys Solids, D-01187 Dresden, Germany

来源：

BIOMACROMOLECULES | 2015年 / 16卷 / 09期

基金：

瑞士国家科学基金会;

关键词：

GELATIN NANOCOMPOSITES; IN-VITRO; COLLAGEN; MORPHOGENESIS; BEHAVIOR; FORM; CRYSTALLIZATION; SUPERSTRUCTURES; POLARIZATION; COMPLEXITY;

D O I：

10.1021/acs.biomac.5b00770

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The correspondence of the state of alignment of macromolecules in biomimetic materials and natural tissues is demonstrated by investigating a mechanism of electrical polarity formation: An in vitro grown biomimetic FAp/gelatin composite is investigated for its polar properties by second harmonic (SHGM) and scanning pyroelectric microscopy (SPEM). Hexagonal prismatic seed crystals formed in gelatin gels represent a monodomain polar state, due to aligned mineralized gelatin molecules. Later growth stages, showing dumbbell morphologies, develop into a bipolar state because of surface recognition by gelatin functionality: A reversal of the polar alignment of macromolecules, thus, takes place close to that basal plane of the seed. In natural hard tissues (teeth and bone investigated by SPEM) and the biomimetic FAp/gelatin composite, we find a surprising analogy in view of growth-induced states of polarity: The development of polarity in vivo and in vitro can be explained by a Markov-type mechanism of molecular recognition during the attachment of macromolecules.

引用

页码：2814 / 2819

页数：6

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