Cardiac transthyretin amyloidosis

被引：100
作者：
Dungu, Jason N. [1 ,2 ]
Anderson, Lisa J. [1 ]
Whelan, Carol J. [2 ]
Hawkins, Philip N. [2 ]
机构：
[1] St Georges Univ London, London SW17 0RE, England
[2] UCL Med Sch, Div Med, Ctr Amyloidosis & Acute Phase Prot, Natl Amyloidosis Ctr, London, England
来源：
HEART | 2012年 / 98卷 / 21期
关键词：
SENILE SYSTEMIC AMYLOIDOSIS; CARDIOVASCULAR MAGNETIC-RESONANCE; HEART-RATE-VARIABILITY; AFRICAN-AMERICANS; P COMPONENT; TC-99M-DPD SCINTIGRAPHY; MONOCLONAL GAMMOPATHY; NATRIURETIC PEPTIDE; CLINICAL-FEATURES; AL AMYLOIDOSIS;
D O I：
10.1136/heartjnl-2012-301924
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiac amyloidosis of transthyretin fibril protein (ATTR) type is an infiltrative cardiomyopathy characterised by ventricular wall thickening and diastolic heart failure. Increased access to cardiovascular magnetic resonance imaging has led to a marked increase in referrals to our centre of Caucasian patients with wild-type ATTR (senile systemic) amyloidosis and Afro-Caribbean patients with the hereditary ATTR V122I type. Both subtypes present predominantly as isolated cardiomyopathy. The differential diagnosis includes cardiac amyloid light-chain (AL) amyloidosis, which has a poorer prognosis and can be amenable to chemotherapy. We review here the clinical features of cardiac ATTR amyloidosis and describe the diagnostic tests to determine ATTR type. Correct diagnosis is ever more crucial given that several novel therapies for ATTR amyloidosis are on the near horizon.
引用
收藏
页码：1546 / 1554
页数：9
相关论文
共 68 条
  • [1] SEPARATION BY HYBRID ISOELECTRIC-FOCUSING OF NORMAL HUMAN-PLASMA TRANSTHYRETIN (PREALBUMIN) AND A VARIANT WITH A METHIONINE FOR VALINE SUBSTITUTION ASSOCIATED WITH FAMILIAL AMYLOIDOTIC POLYNEUROPATHY
    ALTLAND, K
    BANZHOFF, A
    [J]. ELECTROPHORESIS, 1986, 7 (11) : 529 - 533
  • [2] CHANGE IN VARIANT TRANSTHYRETIN LEVELS IN PATIENTS WITH FAMILIAL AMYLOIDOTIC POLYNEUROPATHY TYPE-I FOLLOWING LIVER-TRANSPLANTATION
    ANDO, Y
    TANAKA, Y
    NAKAZATO, M
    BOGORANERICZON
    YAMASHITA, T
    TASHIMA, K
    SAKASHITA, N
    SUGA, M
    UCHINO, M
    ANDO, M
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 211 (02) : 354 - 358
  • [3] Evidence of impaired left ventricular systolic function by Doppler myocardial Imaging in patients with systemic amyloidosis and no evidence of cardiac involvement by standard two-dimensional and Doppler echocardiography
    Bellavia, Diego
    Pellikka, Patricia A.
    Abraham, Theodore P.
    Al-Zahrani, Ghormallah B.
    Dispenzieri, Angela
    Oh, Jae K.
    Bailey, Kent R.
    Wood, Christina M.
    Lacy, Martha Q.
    Miyazaki, Chinami
    Miller, Fletcher A., Jr.
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2008, 101 (07) : 1039 - 1045
  • [4] Benson M.D., 2011, AMYLOID S1, V18, P55
  • [5] The molecular biology and clinical features of amyloid neuropathy
    Benson, Merrill D.
    Kincaid, John C.
    [J]. MUSCLE & NERVE, 2007, 36 (04) : 411 - 423
  • [6] Rate of Progression of Transthyretin Amyloidosis
    Benson, Merrill D.
    Teague, Shawn D.
    Kovacs, Richard
    Feigenbaum, Harvey
    Jung, Jeesun
    Kincaid, John C.
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2011, 108 (02) : 285 - 289
  • [7] The diflunisal trial: update on study drug tolerance and disease progression
    Berk, J. L.
    Dyck, P. J.
    Obici, L.
    Zeldenrust, S. R.
    Sekijima, Y.
    Yamashita, T.
    Ando, Y.
    Ikeda, S. -I.
    Gorevic, P.
    Merlini, G.
    Kelly, J. W.
    Skinner, M.
    Bisbee, A. B.
    Suhr, O. B.
    [J]. AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 2011, 18 : 196 - 197
  • [8] STRUCTURE OF PRE-ALBUMIN - SECONDARY, TERTIARY AND QUATERNARY INTERACTIONS DETERMINED BY FOURIER REFINEMENT AT 1.8-A
    BLAKE, CCF
    GEISOW, MJ
    OATLEY, SJ
    RERAT, B
    RERAT, C
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1978, 121 (03) : 339 - 356
  • [9] Antibodies to human serum amyloid P component eliminate visceral amyloid deposits
    Bodin, Karl
    Ellmerich, Stephan
    Kahan, Melvyn C.
    Tennent, Glenys A.
    Loesch, Andrzej
    Gilbertson, Janet A.
    Hutchinson, Winston L.
    Mangione, Palma P.
    Gallimore, J. Ruth
    Millar, David J.
    Minogue, Shane
    Dhillon, Amar P.
    Taylor, Graham W.
    Bradwell, Arthur R.
    Petrie, Aviva
    Gillmore, Julian D.
    Bellotti, Vittorio
    Botto, Marina
    Hawkins, Philip N.
    Pepys, Mark B.
    [J]. NATURE, 2010, 468 (7320) : 93 - 97
  • [10] Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress
    Brenner, DA
    Jain, M
    Pimentel, DR
    Wang, B
    Connors, LH
    Skinner, M
    Apstein, CS
    Liao, RL
    [J]. CIRCULATION RESEARCH, 2004, 94 (08) : 1008 - 1010
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