Cancer biomarkers

被引：567

作者：

Henry, N. Lynn ^{[1
]}

Hayes, Daniel F. ^{[1
]}

机构：

[1] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

MOLECULAR ONCOLOGY | 2012年 / 6卷 / 02期

关键词：

Biomarker; Cancer; Tumor marker; CLINICAL-PRACTICE GUIDELINE; AMERICAN-SOCIETY; BREAST-CANCER; TUMOR-MARKERS; ADJUVANT CHEMOTHERAPY; MOLECULAR MARKERS; 2006; UPDATE; RECOMMENDATIONS; SERUM; BRCA1;

D O I：

10.1016/j.molonc.2012.01.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Biomarkers have many potential applications in oncology, including risk assessment, screening, differential diagnosis, determination of prognosis, prediction of response to treatment, and monitoring of progression of disease. Because of the critical role that biomarkers play at all stages of disease, it is important that they undergo rigorous evaluation, including analytical validation, clinical validation, and assessment of clinical utility, prior to incorporation into routine clinical care. In this review we address key steps in the development of biomarkers, including ways to avoid introducing bias and guidelines to follow when reporting results of biomarker studies. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：140 / 146

页数：7

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