Exploratory evaluation of two-dimensional and three-dimensional methods of FDG PET quantification in pediatric anaplastic astrocytoma: a report from the Pediatric Brain Tumor Consortium (PBTC)

被引:11
作者
Williams, Gethin [2 ]
Fahey, Frederic H. [1 ,2 ]
Treves, S. Ted [2 ]
Kocak, Mehmet [3 ]
Pollack, Ian F. [4 ]
Boyett, James M. [3 ]
Kun, Larry E. [3 ]
Poussaint, Tina Young [5 ]
机构
[1] Harvard Univ, Childrens Hosp Boston, Sch Med, Dept Radiol,Div Nucl Med, Boston, MA 02115 USA
[2] Harvard Univ, Childrens Hosp Boston, Sch Med, Joint Program Nucl Med, Boston, MA 02115 USA
[3] St Jude Childrens Hosp, Memphis, TN 38105 USA
[4] Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA
[5] Harvard Univ, Childrens Hosp Boston, Sch Med, Dept Radiol,Div Neuroradiol, Boston, MA 02115 USA
关键词
pediatric; anaplastic astrocytoma; PET; FDG; MR;
D O I
10.1007/s00259-008-0780-7
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose The rationale of this study was to investigate the feasibility of three-dimensional (3D) methods to analyze F-18-fluoro-deoxy-glucose (FDG) uptake in children with anaplastic astrocytoma (AA) in a multi-institutional trial, to compare 3D and two-dimensional (2D) methods and explore data associations with progression-free survival (PFS). Methods 3D tumor volumes from pretreatment MR images (fluid attenuation inversion recovery and postgadolinium) of children with recurrent AA on a phase I trial of imatinib mesylate were coregistered to FDG positron emission tomography (PET) images. PET data were normalized. Four metrics were defined: the maximum ratio (maximum pixel value within the 3D tumor volume, normalized), the total ratio (cumulative pixel values within the tumor volume, normalized) and tumor mean ratio (total pixel value divided by volume, normalized). 2D analysis methods were compared. Cox proportional hazards models were used to estimate the association between these methods and PFS. Results Strongest correlations between 2D and 3D methods were with analyses using postcontrast T1 images for volume of interest (VOI). The analyses suggest 3D maximum tumor and mean tumor ratios, whether normalized by gray matter or white matter, were associated with PFS. Conclusions This study of a series of pretreatment AA patients suggests that 3D PET methods using VOIs based on postcontrast T1 correlate with 2D methods and are related to PFS. These methods yield an estimate of metabolically active tumor burden and may add prognostic information after tumor grade is determined. Future rigorous multi-institutional protocols with larger numbers of patients will be required for validation.
引用
收藏
页码:1651 / 1658
页数:8
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