The low carbon building design has become critical given the urgent need to reduce global carbon emissions. Reducing operational energy use through multi-objective optimizations used to be a common approach, but its validity is im-paired by surging embodied impacts. Therefore, a life cycle optimization becomes necessary to improve the overall carbon performance of buildings. However, current research lacks an application of multi-objective optimizations to explore the energy use, carbon emission and cost considering both embodied and operational impacts. Impacts of con-founding design factors and climate change on achieving low carbon designs are also not sufficiently revealed by existing studies. To address these gaps, this study: (i) proposes a parametric design optimization method for low carbon buildings considering cost-effectiveness, (ii) explores the impacts of confounding factors on achieving low carbon de-signs and (iii) evaluates the impact of climate change on the life cycle performance of buildings with proper scenario assumptions. A case study is conducted to explore passive design parameters and integrated photovoltaic (PV) appli-cations to reduce the energy use and carbon emissions in a cost-effective approach. The joint optimization of embodied and operational impacts can reduce the energy use, carbon emission and cost by 42%, 58% and 32%, respectively. Also, variation of confounding factors can lead to different optimized designs with carbon reduction difference up to 75%. The results also show that global warming will lead to higher energy use and carbon emissions in tropical re-gions within the near future, while stringent mitigation strategies aligned with RCP 2.6 can reverse the trend after two decades.