Bis(amino)cyclopropenylidene-Catalyzed 1,6-Conjugate Addition of Aromatic Aldehydes to para-Quinone Methides: Expedient Access to α,α′-Diarylated Ketones

被引：118

作者：

Ramanjaneyulu, Bandaru T. ^{[1
]}

Mahesh, Sriram ^{[1
]}

Anand, Ramasamy Vijaya ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res IISER Mohali, Dept Chem Sci, Sas Nagar 140306, Punjab, India

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 16期

关键词：

N-HETEROCYCLIC CARBENE; CATALYZED ALPHA-ARYLATION; TRANSITION-METAL-COMPLEXES; CARBONYL-COMPOUNDS; ENANTIOSELECTIVE SYNTHESIS; AMBIDENT REACTIVITIES; ACTIVATION STRATEGY; COUPLING REACTIONS; STABLE CARBENES; DIAMINOCYCLOPROPENYLIDENE;

D O I：

10.1021/acs.orglett.5b01724

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A bis(amino)cyclopropenylidene-catalyzed direct method for the synthesis of alpha,alpha'-diarylated ketones from aromatic as well as heteroaromatic aldehydes has been developed. This unprecedented organocatalytic protocol offers access to a wide range of alpha,alpha'-diarylated ketones in moderate to excellent yields under mild conditions through umpolung of aldehydes followed by 1,6-conjugate addition with para-quinone methides.

引用

页码：3952 / 3955

页数：4

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