Chromosomal Abnormalities Are Major Prognostic Factors in Elderly Patients With Multiple Myeloma: The Intergroupe Francophone du Myelome Experience

被引：86

作者：

Avet-Loiseau, Herve ^{[1
]}

Hulin, Cyrille ^{[2
]}

Campion, Loic ^{[3
]}

Rodon, Philippe ^{[4
]}

Marit, Gerald ^{[5
]}

Attal, Michel ^{[1
]}

Royer, Bruno ^{[6
]}

Dib, Mamoun ^{[7
]}

Voillat, Laurent ^{[8
]}

Bouscary, Didier ^{[9
]}

Caillot, Denis ^{[11
]}

Wetterwald, Marc ^{[12
]}

Pegourie, Brigitte ^{[13
]}

Lepeu, Gerard ^{[14
]}

Corront, Bernadette ^{[15
]}

Karlin, Lionel ^{[16
]}

Stoppa, Anne-Marie ^{[17
]}

Fuzibet, Jean-Gabriel ^{[18
]}

Delbrel, Xavier ^{[19
]}

Guilhot, Francois ^{[20
]}

Kolb, Brigitte ^{[21
]}

Decaux, Olivier ^{[22
]}

Lamy, Thierry ^{[22
]}

Garderet, Laurent ^{[10
]}

Allangba, Olivier ^{[23
]}

Lifermann, Francois ^{[24
]}

Anglaret, Bruno ^{[25
]}

Moreau, Philippe ^{[26
]}

Harousseau, Jean-Luc ^{[3
]}

Facon, Thierry ^{[27
]}

机构：

[1] Ctr Hosp Univ, Toulouse, France

[2] Ctr Hosp Univ, Nancy, France

[3] Inst Cancerol Ouest, St Herblain, France

[4] Ctr Hosp, Blois, France

[5] Ctr Hosp Univ, Bordeaux, France

[6] Ctr Hosp Univ, Amiens, France

[7] CHU Angers, Angers, France

[8] Ctr Hosp, Chalon Sur Saone, France

[9] Ctr Hosp Univ Cochin, Paris, France

[10] Ctr Hosp Univ St Antoine, Paris, France

[11] Ctr Hosp Univ, Dijon, France

[12] Ctr Hosp, Dunkerque, France

[13] CHU Grenoble, F-38043 Grenoble, France

[14] Ctr Hosp, Avignon, France

[15] Ctr Hosp, Pringy, France

[16] Ctr Hosp Univ, Lyon, France

[17] Inst J Paoli I Calmettes, F-13009 Marseille, France

[18] CHU Nice, F-06202 Nice, France

[19] Ctr Hosp, Pau, France

[20] Ctr Hosp Univ, Poitiers, France

[21] Ctr Hosp Univ, Reims, France

[22] Ctr Hosp Univ, Rennes, France

[23] Ctr Hosp, St Brieuc, France

[24] Ctr Hosp, Dax, France

[25] Ctr Hosp, Valence, France

[26] CHU Nantes, F-44035 Nantes 01, France

[27] CHU Lille, F-59037 Lille, France

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2013年 / 31卷 / 22期

基金：

美国国家卫生研究院;

关键词：

STEM-CELL TRANSPLANTATION; PREDNISONE; INDUCTION; MELPHALAN;

D O I：

10.1200/JCO.2012.46.2598

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose Chromosomal abnormalities, especially t(4;14) and del(17p), are major prognostic factors in patients with multiple myeloma (MM). However, this has been especially demonstrated in patients age < 66 years treated with intensive approaches. The goal of this study was to address this issue in elderly patients treated with conventional-dose chemotherapy. Patients and Methods To answer this important question, we retrospectively analyzed a series of 1,890 patients (median age, 72 years; range, 66 to 94 years), including 1,095 with updated data on treatment modalities and survival. Results This large study first showed that the incidence of t(4;14) was not uniform over age, with a marked decrease in the oldest patients. Second, it showed that both t(4;14) and del(17p) retained their prognostic value in elderly patients treated with melphalan and prednisone-based chemotherapy. Conclusion t(4;14) and del(17p) are major prognostic factors in elderly patients with MM, both for progression-free and overall survival, indicating that these two abnormalities should be investigated at diagnosis of MM, regardless of age. (C) 2013 by American Society of Clinical Oncology

引用

页码：2806 / +

页数：5

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