Diterpenoids and Sesquiterpenoids from the Roots of Illicium majus

被引：35

作者：

Wang, Ya-Dan ^{[1
,2
]}

Zhang, Gui-Jie ^{[1
,2
]}

Qu, Jing ^{[1
,2
]}

Li, Yu-Huan ^{[2
,3
]}

Jiang, Jian-Dong ^{[1
,2
,3
]}

Liu, Yun-Bao ^{[1
,2
]}

Ma, Shuang-Gang ^{[1
,2
]}

Li, Yong ^{[1
,2
]}

Lv, Hai-Ning ^{[1
,2
]}

Yu, Shi-Shan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 10期

关键词：

PRENYLATED C-6-C-3 COMPOUNDS; NEUROTROPHIC ACTIVITY; STEM BARK; PERICARPS; NEOLIGNANS; LACTONES; PHENYLPROPANOIDS; CONSTITUENTS; DERIVATIVES; GLUCOSIDE;

D O I：

10.1021/np400638r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new diterpenoids (1-5), five new sesquiterpenoids (6-10), and three known compounds (11-13) were isolated from the roots of Illicium majus. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was assigned by X-ray crystallography, whereas those of the 1,2-diol moieties in 3 and 4 were determined using Snatzke's method. The abietane acids 1, 2, 11, 12, and 13 displayed antiviral activity against the Coxsackie B3 virus, with IC50 values of 3.3-51.7 mu M/mL.

引用

页码：1976 / 1983

页数：8

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