Effect of tedizolid on clinical Enterococcus isolates: in vitro activity, distribution of virulence factor, resistance genes and multilocus sequence typing

被引：23
作者：
Bai, Bing [1 ,2 ,3 ]
Hu, Kaitao [1 ,2 ,3 ]
Li, Hui [4 ]
Yao, Weiming [1 ,2 ,3 ]
Li, Duoyun [1 ,2 ,3 ]
Chen, Zhong [1 ,2 ,3 ]
Cheng, Hang [1 ,2 ,3 ]
Zheng, Jinxin [1 ,2 ,3 ,5 ,6 ,7 ]
Pan, Weiguang [1 ,2 ,3 ]
Deng, Minggui [1 ,2 ,3 ]
Liu, Xiaojun [1 ,2 ,3 ]
Lin, Zhiwei [1 ,2 ,3 ,5 ,6 ,7 ]
Deng, Qiwen [1 ,2 ,3 ]
Yu, Zhijian [1 ,2 ,3 ,8 ]
机构：
[1] Shenzhen Univ, Shenzhen Nanshan Hosp, Dept Infect Dis, 89 Taoyuan Rd, Shenzhen 518052, Peoples R China
[2] Shenzhen Univ, Shenzhen Nanshan Hosp, Shenzhen Key Lab Endogenous Infect, 89 Taoyuan Rd, Shenzhen 518052, Peoples R China
[3] Hosp Infect Management, Qual Control Ctr, Shenzhen 518052, Peoples R China
[4] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Digest Dis, Wuhan 430000, Hubei, Peoples R China
[5] Fudan Univ, Sch Basic Med Sci, Key Lab Med Mol Virol, Minist Educ, Shanghai 200032, Peoples R China
[6] Fudan Univ, Sch Basic Med Sci, Key Lab Med Mol Virol, Minist Hlth, Shanghai 200032, Peoples R China
[7] Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Shanghai 200032, Peoples R China
[8] Univ Houston, Dept Pharm Practice & Translat Res, 4849 Calhoun Rd, Houston, TX 77204 USA
来源：
FEMS MICROBIOLOGY LETTERS | 2018年 / 365卷 / 03期
基金：
中国国家自然科学基金;
关键词：
enterococci; tedizolid; in vitro activity; virulence factor; resistance genes; multilocus sequence types; SURVEILLANCE PROGRAM; ANIMAL ORIGIN; UNITED-STATES; FAECIUM; FAECALIS; INFECTIONS; VANCOMYCIN; MANAGEMENT; CFR; STAPHYLOCOCCUS;
D O I：
10.1093/femsle/fnx284
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Enterococcal infections have become one of the most challenging nosocomial problems. Tedizolid, the second oxazolidinone, is 4-fold to 8-fold more potent in vivo and in vitro than linezolid against enterococci. However, the characteristics of tedizolid related to enterococci isolates in China remain elusive. The aim of this study was to evaluate in vitro activity of tedizolid against enterococcal isolates from patients with infections at a teaching hospital in China and to investigate the correlations between in vitro tedizolid activity against enterococci and the distribution of multilocus sequence types (MLST), resistance genes and virulence factors. A total of 289 non-duplicate Enterococcus faecalis strains and 68 E. faecium strains were isolated. Tedizolid inhibited 95.24% of all enterococcal isolates with an MIC <= 0.5 mu g/ml. Seventeen E. faecalis strains had an MIC > 0.5 mu g/ml, and all E. faecium were inhibited at MIC <= 0.5 mu g/ml. The proportion of tedizolid non-susceptible E. faecalis strains with optrA genes was higher than that among tedizolid-susceptible strains. Tedizolid exhibited good in vitro activity against all E. faecium strains, including multidrug-resistant E. faecium carrying tet(M), tet(L), tet(U), erm(A), erm(B) and erm(C) genes. In summary, tedizolid has an advantage (higher sensitivity rate) compared to linezolid among enterococci, except for isolates expressing the plasmid-encoded optrA gene.
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页数：7
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