Brain mast cells link the immune system to anxiety-like behavior

被引:139
作者
Nautiyal, Katherine M. [2 ]
Ribeiro, Ana C. [1 ]
Pfaff, Donald W. [1 ]
Silver, Rae [2 ,3 ,4 ]
机构
[1] Rockefeller Univ, Neurobiol & Behav Lab, New York, NY 10021 USA
[2] Columbia Univ, Dept Psychol, New York, NY 10027 USA
[3] Columbia Univ Barnard Coll, Dept Psychol, New York, NY 10027 USA
[4] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA
关键词
arousal; cromolyn; defecation; psychoneuroimmunology; sash mice;
D O I
10.1073/pnas.0809479105
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Mast cells are resident in the brain and contain numerous mediators, including neurotransmitters, cytokines, and chemokines, that are released in response to a variety of natural and pharmacological triggers. The number of mast cells in the brain fluctuates with stress and various behavioral and endocrine states. These properties suggest that mast cells are poised to influence neural systems underlying behavior. Using genetic and pharmacological loss-of-function models we performed a behavioral screen for arousal responses including emotionality, locomotor, and sensory components. We found that mast cell deficient Kit(W-sh/W-sh) (sash(-/-)) mice had a greater anxiety-like phenotype than WT and heterozygote littermate control animals in the open field arena and elevated plus maze. Second, we show that blockade of brain, but not peripheral, mast cell activation increased anxiety-like behavior. Taken together, the data implicate brain mast cells in the modulation of anxiety-like behavior and provide evidence for the behavioral importance of neuroimmune links.
引用
收藏
页码:18053 / 18057
页数:5
相关论文
共 72 条
[41]   ASTHMA AND EMOTION - A REVIEW [J].
LEHRER, PM ;
ISENBERG, S ;
HOCHRON, SM .
JOURNAL OF ASTHMA, 1993, 30 (01) :5-21
[42]   The spectrum of behaviors influenced by serotonin [J].
Lucki, I .
BIOLOGICAL PSYCHIATRY, 1998, 44 (03) :151-162
[43]   Bi-directional immune-brain communication: Implications for understanding stress, pain, and cognition [J].
Maier, SF .
BRAIN BEHAVIOR AND IMMUNITY, 2003, 17 (02) :69-85
[44]   Mast-cell responses to pathogens [J].
Marshall, JS .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (10) :787-799
[45]   Mast cells and mastocytosis [J].
Metcalfe, Dean D. .
BLOOD, 2008, 112 (04) :946-956
[46]   Estradiol differentially regulates lipocalin-type prostaglandin D synthase transcript levels in the rodent brain:: Evidence from high-density oligonucleotide arrays and in situ hybridization [J].
Mong, JA ;
Devidze, N ;
Frail, DE ;
O'Connor, LT ;
Samuel, M ;
Choleris, E ;
Ogawa, S ;
Pfaff, DW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (01) :318-323
[47]   Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo [J].
Nimmerjahn, A ;
Kirchhoff, F ;
Helmchen, F .
SCIENCE, 2005, 308 (5726) :1314-1318
[48]   Pharmacology of sodium cromoglycate [J].
Norris, AA .
CLINICAL AND EXPERIMENTAL ALLERGY, 1996, 26 :5-7
[49]   COMPARISON OF THE SIZE OF NEURONAL AND NON-NEURONAL HISTAMINE POOLS IN THE BRAIN OF DIFFERENT RAT STRAINS [J].
OISHI, R ;
ITOH, Y ;
FUKUDA, T ;
ARAKI, Y ;
SAEKI, K .
JOURNAL OF NEURAL TRANSMISSION, 1988, 73 (01) :65-69
[50]   A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy [J].
Oliveira, ALR ;
Thams, S ;
Lidman, O ;
Piehl, F ;
Hökfelt, T ;
Kärre, K ;
Lindä, H ;
Cullheim, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (51) :17843-17848