Leptin suppresses basal insulin secretion from rat pancreatic islets

被引：48
|
作者：
Ishida, K
Murakami, T
Mizuno, A
Iida, M
Kuwajima, M
Shima, K
机构：
[1] UNIV TOKUSHIMA,SCH MED,DEPT LAB MED,TOKUSHIMA 770,JAPAN
[2] OTSUKA PHARMACEUT CO LTD,OTSUKA ASSAY LABS,TOKUSHIMA 77101,JAPAN
来源：
REGULATORY PEPTIDES | 1997年 / 70卷 / 2-3期
关键词：
leptin; pancreas; pancreatic islets; insulin secretion;
D O I：
10.1016/S0167-0115(97)01002-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effects of leptin on insulin secretion from pancreatic islets of Sprague-Dawley rats were examined in vitro. In a basal glucose medium (5.5 mM), insulin secretion from isolated islets was significantly decreased after addition of a recombinant leptin (80 nM) (3.20 +/- 0.14 nmol/10 islets/h) compared with that before the addition (4.41 +/- 0.30 nmol/10 islets/h). Although significant leptin suppression of insulin secretion was not observed under a glucose-stimulated (11.1 mM) condition, these results suggest that a negative feedback system may exist between leptin and insulin, which increases the production of leptin from adipose tissues. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：179 / 182
页数：4
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