Study on antibacterial effect of 45S5 BioglassA®

被引：230

作者：

Hu, Sheng ^{[1
]}

Chang, Jiang ^{[1
]}

Liu, Mingqiu ^{[2
]}

Ning, Congqin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, Biomat & Tissue Engn Res Ctr, Shanghai 200050, Peoples R China

[2] Fudan Univ, Sch Life Sci, Inst Genet, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2009年 / 20卷 / 01期

基金：

中国博士后科学基金;

关键词：

BIOACTIVE GLASS; IN-VITRO; PARTICULATE BIOGLASS(R); PENICILLINS; ADHESION; SURFACE; CELLS;

D O I：

10.1007/s10856-008-3564-5

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Previous studies have shown that bioactive glasses possessed antibacterial effect on common bacteria due to the high aqueous pH value caused by the bioactive glass dissolution. In the present study, the efficiency of the antibacterial effect of 45S5 Bioglass(A (R)) (45S5 BAG) against S. aureus, S. epidermidis and E. coli and its mechanism were investigated. The results showed that 45S5 BAG exhibited a strong antibacterial effect against the bacteria, and the sensitivity of gram-negative and gram-positive bacteria to Bioglass was different. Furthermore, a dose-dependent bacterial adhesion on 45S5 BAG particles and the formation of needle-like Bioglass debris were observed, which resulted in the damage of cell walls and inactivation of bacteria. The results suggested that both the high pH and bioglass debris on the surface of bacteria may be the possible mechanisms of the antibacterial effect of 45S5 BAG particulates.

引用

页码：281 / 286

页数：6

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