Phylogenetic and Ecologic Perspectives of a Monkeypox Outbreak, Southern Sudan, 2005

被引：52

作者：

Nakazawa, Yoshinori ^{[1
,2
]}

Emerson, Ginny L. ^{[2
]}

Carroll, Darin S. ^{[2
]}

Zhao, Hui ^{[2
]}

Li, Yu ^{[2
]}

Reynolds, Mary G. ^{[2
]}

Karem, Kevin L. ^{[2
]}

Olson, Victoria A. ^{[2
]}

Lash, R. Ryan ^{[2
]}

Davidson, Whitni B. ^{[2
]}

Smith, Scott K. ^{[2
]}

Levine, Rebecca S. ^{[2
]}

Regnery, Russell L. ^{[2
]}

Sammons, Scott A. ^{[2
]}

Frace, Michael A. ^{[2
]}

Mutasim, Elmangory M. ^{[3
]}

Karsani, Mubarak E. M. ^{[3
]}

Muntasir, Mohammed O. ^{[4
]}

Babiker, Alimagboul A. ^{[4
]}

Opoka, Langova ^{[5
]}

Chowdhary, Vipul ^{[6
]}

Damon, Inger K. ^{[2
]}

机构：

[1] Ctr Dis Control & Prevent, Poxvirus Program, Atlanta, GA 30333 USA

[2] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

[3] Natl Publ Hlth Lab, Khartoum, Sudan

[4] Fed Minist Hlth, Khartoum, Sudan

[5] World Hlth Org Reg Off Eastern Mediterranean, Cairo, Egypt

[6] Med Sans Frontieres, Khartoum, Sudan

来源：

EMERGING INFECTIOUS DISEASES | 2013年 / 19卷 / 02期

关键词：

CLIMATE-CHANGE; GEOGRAPHIC-DISTRIBUTION; NORTH-AMERICA; UNITED-STATES; WEST-AFRICA; CONGO BASIN; NICHE; VIRUS; ORTHOPOXVIRUS; DISTRIBUTIONS;

D O I：

10.3201/eid1902.121220

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Identification of human monkeypox cases during 2005 in southern Sudan (now South Sudan) raised several questions about the natural history of monkeypox virus (MPXV) in Africa. The outbreak area, characterized by seasonally dry riverine grasslands, is not identified as environmentally suitable for MPXV transmission. We examined possible origins of this outbreak by performing phylogenetic analysis of genome sequences of MPXV isolates from the outbreak in Sudan and from differing localities. We also compared the environmental suitability of study localities for monkeypox transmission. Phylogenetically, the viruses isolated from Sudan outbreak specimens belong to a clade identified in the Congo Basin. This finding, added to the political instability of the area during the time of the outbreak, supports the hypothesis of importation by infected animals or humans entering Sudan from the Congo Basin, and person-to-person transmission of virus, rather than transmission of indigenous virus from infected animals to humans.

引用

页码：237 / 245

页数：9

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