Synthesis of 2,5-disubstituted oxazoles via cobalt(III)-catalyzed cross-coupling of N-pivaloyloxyamides and alkynes

被引：20

作者：

Yu, Xiaolong ^{[1
]}

Chen, Kehao ^{[1
]}

Wang, Qi ^{[1
]}

Zhang, Wenjing ^{[1
]}

Zhu, Jin ^{[1
]}

机构：

[1] Nanjing Univ, Collaborat Innovat Ctr Chem Life Sci, Sch Chem & Chem Engn,State Key Lab Coordinat Chem, Dept Polymer Sci & Engn,Nanjing Natl Lab Microstr, Nanjing 210093, Jiangsu, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 10期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; HIGHLY SUBSTITUTED OXAZOLES; ROOM-TEMPERATURE; OXIDATIVE CYCLIZATION; FUNCTIONALIZATION; IODINE; GOLD; DERIVATIVES; ELUCIDATION; 2H-AZIRINES;

D O I：

10.1039/c7cc08611c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of 2,5-disubstituted oxazoles via Co(III) catalysis is described herein. The synthesis is achieved under mild conditions through [3+ 2] cycloaddition of N-pivaloyloxyamides and alkynes. The reaction operates through an internal oxidation pathway and features a very broad substrate scope. The one-step synthesis of natural products such as texamine and balsoxin has been demonstrated via this protocol.

引用

页码：1197 / 1200

页数：4

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