Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidation

被引：21
作者：
Periasamy, Srinivasan [1 ]
Lin, Chia-Hui [1 ]
Nagarajan, Balaji [2 ]
Sankaranarayanan, Nehru Viji [2 ]
Desai, Umesh R. [2 ]
Liu, Ming-Yie [1 ]
机构：
[1] Natl Cheng Kung Univ, Dept Environm & Occupat Hlth, Coll Med, 138 Sheng Li Rd, Tainan 70428, Taiwan
[2] Virginia Commonwealth Univ, Inst Struct Biol Drug Discovery & Dev, Richmond, VA USA
来源：
JOURNAL OF FUNCTIONAL FOODS | 2018年 / 42卷
关键词：
Tamarind xyloglucan; Ulcerative colitis; Oxidative stress; Antioxidant; Mucosal protection; Dietary fiber; INFLAMMATORY-BOWEL-DISEASE; OXIDATIVE STRESS; ETHANOL EXTRACT; MOUSE MODEL; MICE; MECHANISMS; PATHOGENESIS; MICROBIOTA; DIETARY; SEED;
D O I：
10.1016/j.jff.2018.01.014
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Ulcerative colitis (UC) is the leading chronic gastrointestinal disorder, if untreated can cause colon cancer. We characterized tamarind xyloglucan (TXG) as an edible nano-fiber and investigated its role in UC mice. TXG was an efficient free radical quencher and antioxidant in nature. TXG increased the cell viability in DSS-induced cytotoxicity of intestinal epithelial cells (IEC-6) and quenched intracellular reactive oxygen species in IEC-6 cells. Experimental colitis was induced in C57BL/6 mice by administering DSS 3% (w/v) in drinking water; TXG 100 and 300 mg/kg/day were given orally for 7 days simultaneously. TXG protected the colon by attenuating inflammatory cell infiltration, submucosal edema and crypt abscesses. TXG decreased oxidative stress by decreasing MDA, superoxide anion count, iNOS, NOX, COX-2 and p47 expression. Additionally, TXG decreased inflammation by decreasing TNF-alpha and increasing IL-10. Altogether, TXG is a novel antioxidant and plays an important role in attenuating DSS-induced UC in mice.
引用
收藏
页码：327 / 338
页数：12
相关论文
共 43 条
[1]   MECHANISMS OF DISEASE Inflammatory Bowel Disease [J].
Abraham, Clara ;
Cho, Judy H. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (21) :2066-2078
[2]   Le Carbone, a charcoal supplement, modulates DSS-induced acute colitis in mice through activation of AMPKα and downregulation of STAT3 and caspase 3 dependent apoptotic pathways [J].
Afrin, Mst. Rejina ;
Arumugam, Somasundaram ;
Rahman, Md. Azizur ;
Karuppagounder, Vengadeshprabhu ;
Sreedhar, Remya ;
Harima, Meilei ;
Suzuki, Hiroshi ;
Nakamura, Takashi ;
Miyashita, Shizuka ;
Suzuki, Kenji ;
Ueno, Kazuyuki ;
Watanabe, Kenichi .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2017, 43 :70-78
[3]   A pea (Pisum sativum L.) seed albumin extract prevents colonic DSS induced dysbiosis in mice [J].
Aranda-Olmedo, Isabel ;
Ruiz, Raquel ;
Jesus Peinado, M. ;
Rubio, Luis A. .
JOURNAL OF FUNCTIONAL FOODS, 2017, 35 :279-294
[4]   Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment [J].
Basnet, Purusotam ;
Skalko-Basnet, Natasa .
MOLECULES, 2011, 16 (06) :4567-4598
[5]   Intestinal anti-inflammatory effects of Passiflora edulis peel in the dextran sodium sulphate model of mouse colitis [J].
Betim Cazarin, Cinthia Bau ;
Rodriguez-Nogales, Alba ;
Algieri, Francesca ;
Pilar Utrilla, M. ;
Elena Rodriguez-Cabezas, M. ;
Garrido-Mesa, Jose ;
Guerra-Hernandez, Eduardo ;
de Campos Braga, Patricia Aparecida ;
Reyes Reyes, Felix Guillermo ;
Marostica, Mario Roberto, Jr. ;
Galvez, Julio .
JOURNAL OF FUNCTIONAL FOODS, 2016, 26 :565-576
[6]   Formulation of mucoadhesive gastric retentive drug delivery using thiolated xyloglucan [J].
Bhalekar, Mangesh R. ;
Bargaje, Rajesh V. ;
Upadhaya, Prashant G. ;
Madgulkar, Ashwini R. ;
Kshirsagar, Sanjay J. .
CARBOHYDRATE POLYMERS, 2016, 136 :537-542
[7]   OXIDATIVE STRESS: AN ESSENTIAL FACTOR IN THE PATHOGENESIS OF GASTROINTESTINAL MUCOSAL DISEASES [J].
Bhattacharyya, Asima ;
Chattopadhyay, Ranajoy ;
Mitra, Sankar ;
Crowe, Sheila E. .
PHYSIOLOGICAL REVIEWS, 2014, 94 (02) :329-354
[8]   Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo [J].
Bitzer, Zachary T. ;
Wopperer, Amy L. ;
Chrisfield, Benjamin J. ;
Tao, Ling ;
Cooper, Timothy K. ;
Vanamala, Jairam ;
Elias, Ryan J. ;
Hayes, John E. ;
Lambert, Joshua D. .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2017, 40 :201-208
[9]  
Chassaing Benoit, 2014, Curr Protoc Immunol, V104, DOI 10.1002/0471142735.im1525s104
[10]   Standardized ethanolic extract of the rhizome of Curcuma xanthorrhiza prevents murine ulcerative colitis by regulation of inflammation [J].
Cho, Jae Young ;
Kim, Hwa Yeon ;
Kim, Hye Me ;
Song, Ha Na ;
Hong, Eunyoung ;
Hwang, Jae-Kwan ;
Chun, Hyang Sook .
JOURNAL OF FUNCTIONAL FOODS, 2017, 30 :282-289
12345