Absolute stereochemistry of cicutoxin and related toxic polyacetylenic alcohols from Cicuta virosa

被引：29

作者：

Ohta, T ^{[1
]}

Uwai, K

Kikuchi, R

Nozoe, S

Oshima, Y

Sasaki, K

Yoshizaki, F

机构：

[1] Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9200934, Japan

[2] Tohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi 9800856, Japan

[3] Tohoku Coll Pharm, Sendai, Miyagi 9810905, Japan

来源：

TETRAHEDRON | 1999年 / 55卷 / 41期

关键词：

polyacetylenic alcohols; optical properties; stereochemistry;

D O I：

10.1016/S0040-4020(99)00706-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The absolute stereostructures of cicutoxin (1) and related toxic polyacetylenic alcohols, isocicutoxin (2), and virols A (3) and C (4), from Cicuta virosa were determined on the basis of spectroscopic analysis. The CD exciton chirality method was successfully applied to 4-methoxybenzoates of dyne-conjugated polyenyl alcohol systems. Fatal doses of these compounds on mice are also reported. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：12087 / 12098

页数：12

共 2 条

[1] Determination of the absolute stereochemistry of chiral secondary megastigmane alcohols from Shiraz leaves by NMR studies
Skouroumounis, GK
Gunata, YZ
Baumes, RL
JOURNAL OF ESSENTIAL OIL RESEARCH, 2000, 12 (06) : 661 - 666
[2] Metabolites from the sponge Plakortis simplex.: Determination of absolute stereochemistry of plakortin.: Isolation and stereostructure of three plakortin related compounds
Cafieri, F
Fattorusso, E
Taglialatela-Scafati, O
Ianaro, A
TETRAHEDRON, 1999, 55 (22) : 7045 - 7056

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