Multiple Idiopathic Cervical Root Resorption: A Challenge for a Transdisciplinary Medical-Dental Team

被引:17
作者
Chu, Emily Y. [1 ]
Deeb, Janina Golob [2 ]
Foster, Brian L. [3 ]
Hajishengallis, Evlambia [4 ]
Somerman, Martha J. [1 ]
Thumbigere-Math, Vivek [1 ,5 ]
机构
[1] NIAMSD, NIH, Bethesda, MD 20892 USA
[2] Virginia Commonwealth Univ, Sch Dent, Dept Periodont, Richmond, VA USA
[3] Ohio State Univ, Coll Dent, Div Biosci, Columbus, OH USA
[4] Univ Penn, Div Pediat Dent, Sch Dent Med, Philadelphia, PA USA
[5] Univ Maryland, Sch Dent, Div Periodont, Baltimore, MD 21201 USA
来源
FRONTIERS IN DENTAL MEDICINE | 2021年 / 2卷
关键词
periodontal disease; root resorption; osteoclast; odontoclast; genetics; medications; bone resorption; FAMILIAL EXPANSILE OSTEOLYSIS; RISK-FACTORS; TOOTH RESORPTION; FELINE TEETH; LESIONS; HYPOPHOSPHATASIA; CLASSIFICATION; PATHOGENESIS; PREVALENCE; ETIOLOGY;
D O I
10.3389/fdmed.2021.652605
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The goal of this perspective article is to use multiple idiopathic cervical root resorption (MICRR) as a model to demonstrate the need for transdisciplinary collaborations, from basic science to treatment planning, to improve the quality of health care for all. This is not a review of the literature on the current state of MICRR. Tooth root resorption is a normal physiological process required for resorption and exfoliation of primary teeth; however, root resorption of adult teeth is largely pathological. MICRR is an aggressive form of external root resorption, which occurs near the cemento-enamel junction (CEJ). The cause of MICRR remains elusive, however, it is mediated primarily by osteoclasts/odontoclasts. Accumulating case studies and experiments in animal models have provided insights into defining the etiologies and pathophysiological mechanisms for MICRR, which include: systemic conditions and syndromes, inherited genetic variants affecting osteoclast/odontoclast activity, altered periodontal structures, drug-induced root resorption and rebound effects after cessation of anti-resorptive treatment, chemotherapy, exposure to pets or viral infections, and other factors such as inflammatory conditions or trauma. To determine the causative factors for MICRR, as well as other oral-dental conditions, at minimum, a comprehensive health history should be collected for all patients by dental care providers, discussed with other health care providers and appropriate collaborations established. The examples highlighted in this perspective emphasize the need for transdisciplinary research collaborations coupled with integrated management strategies between medicine and dentistry in order to identify cause(s) early and improve clinical outcomes.
引用
收藏
页数:9
相关论文
共 88 条
[81]  
Wan Jason T, 2020, [Bone Research, 骨研究], V8, P14
[82]   Hypophosphatasia: An overview For 2017 [J].
Whyte, Michael P. .
BONE, 2017, 102 :15-25
[83]   Hypophosphatasia - aetiology, nosology, pathogenesis, diagnosis and treatment [J].
Whyte, Michael P. .
NATURE REVIEWS ENDOCRINOLOGY, 2016, 12 (04) :233-246
[84]   Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets [J].
Wong, Kok Loon ;
Tai, June Jing-Yi ;
Wong, Wing-Cheong ;
Han, Hao ;
Sem, Xiaohui ;
Yeap, Wei-Hseun ;
Kourilsky, Philippe ;
Wong, Siew-Cheng .
BLOOD, 2011, 118 (05) :E15-E30
[85]   Multiple idiopathic cervical root resorption: a case report [J].
Wu, J. ;
Lin, L. Y. ;
Yang, J. ;
Chen, X. F. ;
Ge, J. Y. ;
Wu, J. R. ;
Sun, W. B. .
INTERNATIONAL ENDODONTIC JOURNAL, 2016, 49 (02) :189-202
[86]   Multiple idiopathic cervical resorption: case report and discussion of management options [J].
Yu, V. S. H. ;
Messer, H. H. ;
Tan, K. B. .
INTERNATIONAL ENDODONTIC JOURNAL, 2011, 44 (01) :77-85
[87]   MULTIPLE EXTERNAL ROOT RESORPTION [J].
YUSOF, WZ ;
GHAZALI, MN .
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION, 1989, 118 (04) :453-455
[88]   Bisphosphonates as Supplement to Dental Treatment: A Network Meta-Analysis [J].
Zymperdikas, V. F. ;
Yavropoulou, M. P. ;
Kaklamanos, E. G. ;
Papadopoulos, M. A. .
JOURNAL OF DENTAL RESEARCH, 2021, 100 (04) :341-351