Study on synthesis and biological reactivity of ternary complex palladium (II)-biquinoline-malonate

被引：0
|
作者：
Gao, EJ [1 ]
Zhao, SM
Liu, QT
Xu, R
机构：
[1] Shenyang Inst Chem Technol, Coordinat Chem Sect, Shenyang 110142, Peoples R China
[2] Liaoning Univ, Dept Sci & Chem Engn, Shenyang 110036, Peoples R China
[3] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China
来源：
ACTA CHIMICA SINICA | 2004年 / 62卷 / 06期
关键词：
palladium(II); ternary complex; DNA; intercalation; anticancer activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The ternary complex [Pd(biqu)(mal)] (.) H2O (in which biqu is 2,2'-biquinoline, and mal is malonate) was synthesized, its inhibition activity against lung cancer cell AGZY-83a was observed with IC50 of 21.9mug(.)mL(-1), and the interaction of the complex with sperm DNA was determined by fluorescent spectra, UV-spectra and CD-spectra. The binding constant (K-M) of the complex and sperm DNA is 2.03 x 10(8) and its interaction with pBR322 plasmid DNA was also determined by gel electrophoresis. The results show that the complex interacted with DNA mainly by intercalative mode.
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页码：593 / 597
页数：5
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