Copper(0) Nanoparticles in Click Chemistry: Synthesis of 3,5-Disubstituted Isoxazoles

被引：14

作者：

Vishwanatha, T. M. ^{[1
]}

Sureshbabu, Vommina V. ^{[1
]}

机构：

[1] Bangalore Univ, Dept Studies Chem, Peptide Res Lab, Bangalore 560001, Karnataka, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 52卷 / 06期

关键词：

RUTHENIUM-CATALYZED CYCLOADDITION; ULLMANN COUPLING REACTION; ONE-POT SYNTHESIS; TERMINAL ALKYNES; ARYL HALIDES; COPPER(I)-CATALYZED SYNTHESIS; METAL NANOPARTICLES; REUSABLE CATALYST; NITRILE OXIDES; AZIDES;

D O I：

10.1002/jhet.2065

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient procedure for the synthesis of 3,5-disubstituted isoxazoles via [3+2] cycloaddition reaction of in situ generated nitrile oxides with acetylenes employing readily preparable copper(0) nanoparticles is described. A variety of in situ generated nitrile oxide and acetylenic substrates were engaged in the study and found to undergo cyclization in short duration affording respective isoxazoles in excellent yield. Several amino acid-derived isoxazoles were also prepared in high yield. Consistent activity of the recovered catalyst was found to be almost same up to three cycles.

引用

页码：1823 / 1833

页数：11

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