Hydroxylated Polybrominated Diphenyl Ethers in Paired Maternal and Cord Sera

被引：73

作者：

Chen, Aimin ^{[1
]}

Park, June-Soo ^{[2
]}

Linderholm, Linda ^{[2
]}

Rhee, Alexandra ^{[2
]}

Petreas, Myrto ^{[2
]}

DeFranco, Emily A. ^{[3
]}

Dietrich, Kim N. ^{[1
]}

Ho, Shuk-mei ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Div Epidemiol & Biostat, Dept Environm Hlth,Ctr Environm Genet, Cincinnati, OH 45267 USA

[2] Calif Environm Protect Agcy, Environm Chem Lab, Calif Dept Tox Subst Control, Berkeley, CA USA

[3] Univ Cincinnati, Coll Med, Div Maternal Fetal Med, Dept Obstet & Gynecol, Cincinnati, OH 45267 USA

来源：

ENVIRONMENTAL SCIENCE & TECHNOLOGY | 2013年 / 47卷 / 08期

关键词：

BROMINATED FLAME RETARDANTS; POLYCHLORINATED-BIPHENYLS; PREGNANT-WOMEN; BREAST-MILK; PRENATAL EXPOSURE; THYROID-HORMONES; BLOOD; POPULATION; PBDES; FETAL;

D O I：

10.1021/es3046839

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Polybrominated diphenyl ethers (PBDEs) were widely used as flame retardants in the past three decades. These compounds are lipophilic and easily cross the placenta from pregnant woman to fetus. It is not clear whether hydroxylated PBDEs (OH-PBDEs), with greater hydrophilicity, have different concentrations in maternal and cord serum samples. We analyzed PBDEs (BDE-28, -47, -99, -100, -153, -154, -209) and OH-PBDEs (6-OH-BDE-47, 5-OH-BDE-47, 4'-OH-BDE-49, 5'-OH-BDE-99) in 20 pairs of maternal and cord serum samples collected in Cincinnati, OH in 2011. The geometric mean concentration of Sigma OH-BDEs (the sum of four OH-PBDEs) was 49.76 pg/mL in cord sera, higher than 32.84 pg/mL in maternal sera. Similarly, cord serum total BDEs had a higher geometric mean than maternal serum (45.51 vs 32.07 ng/g lipid). Equal or higher levels of total OH-BDEs and total BDEs in cord serum were observed in 85% and 80% of the mother-neonate pairs, respectively. The study suggests fetuses might receive higher OH-PBDE and PBDE exposure than their mothers.

引用

页码：3902 / 3908

页数：7

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