Signal transduction pathway for anterior-posterior development in Drosophila

被引：0

作者：

Baek, KH

Lee, KY

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Pediat Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 1999年 / 6卷 / 05期

关键词：

signal transduction; receptor tyrosine kinase; oncogene; Raf;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In Drosophila, the establishment of embryonic polarity along the anterior-posterior axis of the egg is determined by the activity of maternal gene products that accumulate during oogenesis, Amongst these are the Bicoid, the Nanos, and the terminal class gene products, some of which are oncoproteins involved in signal transduction for the formation of terminal structures in the embryo. Several signal transduction pathways have been described in Drosophila, and this review explores the potential of oncogene studies using one of those pathways - the terminal class signal transduction pathway - to better understand the cellular mechanisms of proto-oncogenes that mediate cellular responses in vertebrates including humans.

引用

页码：314 / 319

页数：6

共 58 条

[1] The activity of D-raf in Torso signal transduction is altered by serine substitution, N-terminal deletion, and membrane targeting [J].