Endothelial activation: intracellular signaling pathways

被引：157
|
作者：
Pober, Jordan S. [1 ]
机构：
[1] Yale Univ, Boyer Ctr Mol Med, Sch Med, 295 Congress Ave,Room 454, New Haven, CT 06510 USA
来源：
ARTHRITIS RESEARCH & THERAPY | 2002年 / 4卷 / Suppl 3期
关键词：
adhesion molecules; cytokines; inflammation; leukocytes; tumor necrosis factor;
D O I：
10.1186/ar576
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the expression of adhesion molecules.
引用
收藏
页码：S109 / S116
页数：8
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