The responsiveness and validity of the CAMPHOR Utility Index

被引：38

作者：

Meads, D. M. ^{[1
]}

Mckenna, S. P. ^{[1
,2
]}

Doughty, H. ^{[3
]}

Das, C. ^{[4
]}

Gin-Sing, W. ^{[5
]}

Langley, J. ^{[6
]}

Pepke-Zaba, J. ^{[3
]}

机构：

[1] Galen Res, Manchester M15 6SE, Lancs, England

[2] Univ Cent Lancashire, Sch Psychol, Preston PR1 2HE, Lancs, England

[3] Papworth Hosp NHS Trust, Pulm Vasc Dis Unit, Papworth Everard, England

[4] Royal Free Hosp, Dept Cardiol, London NW3 2QG, England

[5] Hammersmith Hosp, Dept Cardiol, London, England

[6] Actel Pharmaceut UK, London, England

来源：

EUROPEAN RESPIRATORY JOURNAL | 2008年 / 32卷 / 06期

关键词：

Bosentan; Cambridge Pulmonary Hypertension Outcome Review; pulmonary hypertension; quality of life; responsiveness; utility;

D O I：

10.1183/09031936.00069708

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The aim of the present study was to validate and determine the mininal important difference (MID) and responsiveness of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) Utility Index, a new tool enabling cost utility analyses. CAMPHOR, 6-min walking test (6MWT) and New York Heart Association (NYHA) data for 869 pulmonary hypertension patients (545 (63%) female; mean +/- SD age 56.6 +/- 15.4 yrs) from three centres were analysed. Utility was correlated with 6MWT data and calculated by NYHA class to assess validity. Effect sizes were calculated for those with two CAMPHOR assessments. Distribution and anchor-based MIDs were calculated. Analyses were carried out in patients receiving bosentan in order to determine whether or not those remaining in NYHA class III following treatment improved. The Utility Index distinguished between adjacent NYHA classes and correlated with 6MWT results. CAMPHOR subscales and utility were as responsive as the 6MWT (effect sizes ranged 0.31-0.69 for the CAMPHOR and 0.16-0.34 for the 6MWT). The within-group MID for the Utility Index was estimated to be similar to 0.09. Patients remaining in NYHA class III experienced, on average, a significant improvement (CAMPHOR Utility Index and functioning), which exceeded the MID. The CAMPHOR Utility Index is valid and responsive to change. Patients can experience significant and important improvements even if they do not improve on the basis of traditional outcomes, such as NYHA functional class.

引用

页码：1513 / 1519

页数：7

共 33 条

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