Electrochemical S-H and O-H insertion reactions from thiols or salicylic acids with diazo esters

被引：9

作者：

He, Zhiqin ^{[1
]}

Zhao, Wei ^{[1
]}

Li, Yufeng ^{[1
]}

Yu, Yang ^{[3
]}

Huang, Fei ^{[1
,2
]}

机构：

[1] Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210023, Peoples R China

[2] Nanjing Tech Univ, Sch Pharmaceut Sci, Nanjing 211816, Peoples R China

[3] Nanjing Tech Univ, Sch Environm Sci & Engn, Nanjing 211816, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 41期

基金：

中国国家自然科学基金;

关键词：

MODIFIED SEWAGE-SLUDGE; BOND INSERTION; CATALYZED INSERTION; VERSATILE SYNTHONS;

D O I：

10.1039/d2ob01273a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An electrochemical carbenoid insertion reaction of diazo compounds into C-S and C-O bonds with electricity as the oxidant has been reported in this work. In this protocol, this transformation proceeded smoothly under mild conditions at room temperature in the absence of a catalyst and a ligand. In addition, the yield of the S-H insertion product was up to 96% and the O-H product could be efficiently obtained in up to 80% yield. Of note is that this environmentally friendly strategy exhibited excellent applicability in gram-scale synthesis.

引用

页码：8078 / 8082

页数：5

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