Crystal Structure and Conformation of an 2-Amino-1,3-thiazine Derivative

被引：0

作者：

Zhao Ming-Qin ^{[1
]}

Shao Hui-Fang ^{[1
]}

Ji Xiao-Ming ^{[1
]}

机构：

[1] Henan Univ Agr, Coll Agron, Zhengzhou 450002, Peoples R China

来源：

CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2008年 / 27卷 / 10期

关键词：

thiazine; sugar; synthesis; X-ray crystallographic analysis;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Thiazine sugar derivative 2 was synthesized and characterized by IR, NMR and H RMS, and its crystal structure was determined by X-ray diffraction analysis. The crystal is of monoclinic system (C16H24N2O8S2, M-r = 436.49) with space group P2(1), a = 10.311(2), b 9.1198(18), c = 11.623(2) angstrom, beta = 109.47(3)degrees, V = 1030.4(4) angstrom(3), Z = 2, D-c = 1.407 g/cm(3), F(000) = 460, mu = 0.303 mm(-1), the final R = 0.0437 and wR = 0.0561 for 1954 observed reflections (I> 2 sigma(I)). Nine hydrogen bonds were found. The absolute configuration of this molecule was confirmed by comparison with the original material.

引用

页码：1240 / 1244

页数：5

共 14 条

[1]

HU HW, 1990, CHINESE J ORG CHEM, P61

[2]

KERWIN JF, 1994, MED RES REV, V37, P1899

[3] APPROACHES TOWARD SELECTIVE-INHIBITION OF NITRIC-OXIDE SYNTHASE [J].

MARLETTA, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (13) :1899-1907

[4] 2-iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms [J].

Moore, WM ;

Webber, RK ;

Fok, KF ;

Jerome, GM ;

Connor, JR ;

Manning, PT ;

Wyatt, PS ;

Misko, TP ;

Tjoeng, FS ;

Currie, MG .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (03) :669-672

[5]

NING YC, 2002, STRUCTURAL IDENTIFIC, P116

[6]

ONODERA KONOSHIN, 1968, CARBOHYD RES, V6, P276, DOI 10.1016/S0008-6215(00)81449-4

[7]

PENG SX, 2000, HUAXUE JINZHAN, P137

[8]

SHAH SK, 1996, Patent No. 9614842

[9]

SHAH SK, 1999, J BIO CHEM, V272, P993

[10]

SHELDRICK GM, 1997, SHELXS97 SHELXL97 U

← 1 2 →