Bronsted Acid-Mediated Domino One-Pot Dual C-C Bond Formation: Chemoselective Synthesis of Fused Tricyclic Ketones

被引：9

作者：

Niharika, Pedireddi ^{[1
]}

Ramulu, Bokka Venkat ^{[1
]}

Satyanarayana, Gedu ^{[1
]}

机构：

[1] IIT Hyderabad, Kandi 502285, Telangana, India

来源：

ACS OMEGA | 2018年 / 3卷 / 01期

关键词：

FRIEDEL-CRAFTS ACYLATION; MARINE VERRUCOSISPORA STRAIN; CARBONYL-OLEFIN METATHESIS; RAY CRYSTAL-STRUCTURES; FACILE SYNTHESIS; SPIROCYCLIC SCAFFOLDS; LEWIS; CYCLIZATION; CORE; CATALYSIS;

D O I：

10.1021/acsomega.7b01553

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A chemoselective synthesis of fused novel tricyclic motifs via a facile domino intramolecular cyclization is presented. The strategy enables the formation of dual C-C bond via intramolecular Friedel-Crafts alkylation followed by acylation to accomplish fused tricyclic ketones. Significantly, these fused tricyclic compounds are ubiquitous and constitute major structural cores of natural products.

引用

收藏

页码：218 / 228

页数：11

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