Modelling, abstraction, and computation in systems biology: A view from computer science

被引：12

作者：

Melham, Tom ^{[1
]}

机构：

[1] Univ Oxford, Dept Comp Sci, Oxford OX1 3QD, England

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2013年 / 111卷 / 2-3期

关键词：

Algorithmic biological modelling; Abstraction; Multi-scale modelling; Biological computation; PETRI NETS; CELL; PATHWAY;

D O I：

10.1016/j.pbiomolbio.2012.08.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Systems biology is centrally engaged with computational modelling across multiple scales and at many levels of abstraction. Formal modelling, precise and formalised abstraction relationships, and computation also lie at the heart of computer science-and over the past decade a growing number of computer scientists have been bringing their discipline's core intellectual and computational tools to bear on biology in fascinating new ways. This paper explores some of the apparent points of contact between the two fields, in the context of a multi-disciplinary discussion on conceptual foundations of systems biology. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：129 / 136

页数：8

共 72 条

[1]

[Anonymous], 1993, CAMBRIDGE TRACTS THE

[2]

[Anonymous], 2006, INTRO AUTOMATA THEOR

[3]

Baier C, 2008, PRINCIPLES OF MODEL CHECKING, P1

[4] Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases [J].