Quinazoline-sulfonamides as potential antitumor agents: synthesis and biological testing

被引：6

作者：

Alafeefy, Ahmed M. ^{[1
]}

Alqasoumi, Saleh I. ^{[2
]}

Ashour, Abdelkader E. ^{[3
]}

Alshebly, Mashael M. ^{[4
]}

机构：

[1] Salman Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut Chem, Al Kharj 11942, Saudi Arabia

[2] King Saud Univ, Coll Med, Dept Pharmacognosy, Riyadh 11461, Saudi Arabia

[3] King Saud Univ, Coll Med, Dept Pharmacol & Toxicol, Riyadh 11461, Saudi Arabia

[4] King Saud Univ, Coll Med, Dept Obstet & Gynaecol, Riyadh 11461, Saudi Arabia

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2013年 / 28卷 / 02期

关键词：

Antitumor; quinazoline; sulfonamide; synthesis; CARBONIC-ANHYDRASE; CELL-CYCLE; INHIBITORS; DERIVATIVES; DESIGN; DRUGS;

D O I：

10.3109/14756366.2012.668541

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New series of quinazoline containing sulfonamide derivatives were prepared and screened for their antitumor activity. Four human cancer cell lines, namely, hepatoma cancer cell line (HepG2), breast cancer cell line (MCF-7), cervix cancer cell line (HeLa) and colon cancer cell line (HCT-8), were used to measure the cytotoxic activity. Compounds 8 and 21 exhibited remarkable antitumor activity almost similar to that of the standard drug (doxorubicin). Six compounds 16, 22, 23, 29, 30 and 33, showed considerable activity and few compounds were totally inactive.

引用

页码：375 / 383

页数：9

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