α1-Adrenoceptor agonists:: The identification of novel α1A subtype selective 2′-heteroaryl-2-(phenoxymethyl)imidazolines

被引：17

作者：

Bishop, MJ ^{[1
]}

Barvian, KA ^{[1
]}

Berman, J ^{[1
]}

Bigham, EC ^{[1
]}

Garrison, DT ^{[1
]}

Gobel, MJ ^{[1
]}

Hodson, SJ ^{[1
]}

Irving, PE ^{[1
]}

Liacos, JA ^{[1
]}

Navas, F ^{[1
]}

Saussy, DL ^{[1
]}

Speake, JD ^{[1
]}

机构：

[1] GlaxoSmithKline R&D, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)00764-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel 2'-heteroaryl-2-(phenoxymethyl)imidazolines have been identified as potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The nature of the 2'-heteroaryl group can have significant effects on the potency, efficacy, and subtype selectivity in this series. alpha(1A) Subtype selective agonists have been identified. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：471 / 475

页数：5

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