Mechanisms of Aspirin Desensitization

被引：12

作者：

Burnett, Trever ^{[1
]}

Katial, Rohit ^{[2
]}

Alam, Rafeul ^{[3
]}

机构：

[1] Univ Colorado, Natl Jewish Med & Res Ctr, Dept Allergy & Immunol, Adult Program, Denver, CO 80206 USA

[2] Univ Colorado, Natl Jewish Med & Res Ctr, Dept Allergy & Immunol, Weinberg Clin Res Unit,Adult Fellowship Program, Denver, CO 80206 USA

[3] Univ Colorado, Natl Jewish Med & Res Ctr, Div Allergy & Immunol, Denver, CO 80206 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2013年 / 33卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Aspirin-exacerbated respiratory disease (AERD); Aspirin desensitization; Mechanisms of action; Cysteinyl leukotrienes (CysLTs); Cytokines; Interleukin 4 (IL-4); Signal transducer and activator of transcription 6 (STAT6); SENSITIVE ASTHMATIC SUBJECTS; ACTIVATED PROTEIN-KINASE; EXACERBATED RESPIRATORY-DISEASE; LEUKOTRIENE-RECEPTOR EXPRESSION; KAPPA-B; URINARY LEUKOTRIENE-E4; CYSTEINYL-LEUKOTRIENES; CHRONIC RHINOSINUSITIS; INFLAMMATORY CELLS; BRONCHIAL BIOPSIES;

D O I：

10.1016/j.iac.2012.11.003

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Aspirin-exacerbated respiratory disease is a clinical syndrome characterized by severe, persistent asthma, hyperplastic eosinophilic sinusitis with nasal polyps, and reactions to aspirin and other nonsteroidal antiinflammatory drugs that preferentially inhibit cyclooxygenase 1. The mechanisms behind the therapeutic effects of aspirin desensitization remain poorly understood. Recent studies suggest that the clinical benefits may occur through direct inhibition of tyrosine kinases and the signal transducer and activator of transcription 6 signaling pathway, which results in inhibition of interleukin 4 production. In this article, the current understanding of the mechanisms of aspirin desensitization is reviewed and future areas of investigation are discussed.

引用

页码：223 / +

页数：16

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