Catalysis and regioselectivity in the Michael addition of azoles, kinetic vs thermodynamic control

被引：49
作者：
Horvath, A
机构：
[1] Alkaloida Chemical Company Ltd., H-4440 Tiszavasvári
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 25期
关键词：
D O I：
10.1016/0040-4039(96)00845-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Bicyclic guanidine bases, TBD and MTBD were found to be highly efficient catalysts in the Michael addition of azoles with alpha,beta-unsaturated nitriles and esters. The factors influencing regioselectivity have been elucidated, and some new azole-Michael adducts were synthesized. These were shown to be useful starting compounds for the regioselective N-alkylation of the corresponding azoles. Copyright (C) 1996 Elsevier Science Ltd
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页码：4423 / 4426
页数：4
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