Resonance assignments of the metal sensor CzrA in the apo-, Zn2- and DNA-bound (42 kDa) states

被引：12

作者：

Arunkumar, Alphonse I. ^{[2
]}

Pennella, Mario A. ^{[2
]}

Kong, Xiangming ^{[2
]}

Giedroc, David P. ^{[1
,2
]}

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

[2] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA

来源：

BIOMOLECULAR NMR ASSIGNMENTS | 2007年 / 1卷 / 01期

关键词：

metal sensor; czr O/P; transcriptional repressor; winged helix; DNA binding; allosteric regulation;

D O I：

10.1007/s12104-007-9027-y

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Zn/Co binding to homodimeric CzrA de-represses transcription of the czr (cobalt zinc resistance) operon in Staphylococcus aureus. Essentially complete backbone and stereospecific methyl group resonance assignments for apo-, Zn(2) and a 42 kDa apo- CzrA-DNA complex are presented.

引用

页码：99 / 101

页数：3

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