Synthesis, Characterization and Biological Evaluation of Some New Pyrazoline Derivatives

被引：0

作者：

Jain, Dinesh Kumar ^{[1
]}

Bhadoriya, Upendra ^{[1
]}

Lodhi, Jawahar Lal ^{[1
]}

机构：

[1] IPS Acad, Coll Pharm, Indore 452012, Madhya Pradesh, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 03期

关键词：

Pyrazoline; Antitubercular activity; Chalcone; Hydrazine hydrate;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pyrazoline derivatives have been found to possess appreciable antitubercular activity against Mycobacterium tuberculosis. The present study aimed to synthesize some potent antitubercular pyrazoline derivatives. Different substituted pyrazoline derivatives were synthesized by cyclization of substituted chalcone derivatives in presence of hydrazine hydrate. Synthesized derivative were characterized by melting point, TLC, FT-IR, H-1 MR and MS spectrometry. Synthesized derivatives were evaluated for their in vitro antitubercular activity against M. tuberculosis. Derivatives JA(1), JA(2), JA(3) and JA(5) were found to be most potent and showed greater zone of inhibition than control which, is comparable to standard drug rifampicin.

引用

页码：1387 / 1390

页数：4

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