Determination of bromide in canine plasma using ion chromatography

被引：1
|
作者：
Cox, S. K. [1 ]
Whiton, A. M. [1 ]
Bowman, H. L. [1 ]
机构：
[1] Univ Tennessee, Coll Vet Med, Dept Comparat Med, Knoxville, TN 37996 USA
来源：
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2008年 / 870卷 / 02期
关键词：
ion chromatography; bromide; epilepsy;
D O I：
10.1016/j.jchromb.2008.06.023
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A new ion chromatographic procedure has been developed and validated for the determination of bromide in canine plasma. Following a simple dilution, samples were separated on a Metrosep A Supp 5 column. The mobile phase was an isocratic mixture of 2.2 mM Na2CO3, 1.0 mM NaHCO3, and 1% acetonitrile, with a flow-rate of 0.7 ml/min. The procedure produced a linear curve over the concentration range of 50-2500 mu Lg/ml. The development of the assay permitted the determination of therapeutic levels after oral administration of potassium bromide to dogs being treated for epilepsy. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：255 / 258
页数：4
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