Fast and Green One-Pot Multicomponent Synthesis of a Library of Pyrrolo[1,2-c]Pyrimidines Under Microwave Irradiation

被引：11

作者：

Georgescu, Emilian ^{[1
]}

Georgescu, Florentina ^{[1
]}

Draghici, Constantin ^{[2
]}

Cristian, Liliana ^{[2
]}

Popa, Marcel Mirel ^{[2
]}

Dumitrascu, Florea ^{[2
]}

机构：

[1] Res Ctr Oltchim, Ramnicu Valcea 240050, Romania

[2] Romanian Acad, Ctr Organ Chem CD Nenitzescu, Bucharest 060023, Romania

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2013年 / 16卷 / 10期

关键词：

1,3-dipolar cycloaddition; microwaves; multicomponent reaction; N-ylide; pyrrolo[1,2-c]pyrimidine; PYRIMIDINIUM YLIDES; 4-METHYLPYRIMIDINIUM YLIDES; 1,3-DIPOLAR CYCLOADDITION; 3-COMPONENT SYNTHESIS; ASSISTED SYNTHESIS; HETEROCYCLES; REACTIVITY; STABILITY; EFFICIENT; DERIVATIVES;

D O I：

10.2174/13862073113169990050

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones and nonsymmetrical, electron deficient alkynes in 1,2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component synthesis implies short reaction times being at the same time highly cost-effective and environmental friendly. [GRAPHICS] .

引用

收藏

页码：851 / 857

页数：7

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