Biomarkers and Molecular Imaging as Predictors of Response to Neoadjuvant Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer

被引：35

作者：

Molinari, Chiara ^{[1
]}

Matteucci, Federica ^{[2
]}

Caroli, Paola ^{[2
]}

Passardi, Alessandro ^{[3
]}

机构：

[1] IRCCS, Ist Sci Romagnolo Studio & Cura Tumori IRST, Biosci Lab, I-47014 Meldola, Italy

[2] IRCCS, Ist Sci Romagnolo Studio & Cura Tumori IRST, Diagnost Nucl Med Unit, I-47014 Meldola, Italy

[3] IRCCS, Ist Sci Romagnolo Studio & Cura Tumori IRST, Dept Med Oncol, I-47014 Meldola, Italy

来源：

CLINICAL COLORECTAL CANCER | 2015年 / 14卷 / 04期

关键词：

LARC; MRI; NCRT; PET-CT; Predictive markers; POSITRON-EMISSION-TOMOGRAPHY; WEIGHTED MAGNETIC-RESONANCE; RECEIVING PREOPERATIVE CHEMORADIATION; PATHOLOGICAL TUMOR RESPONSE; COLORECTAL-CANCER; CARCINOEMBRYONIC ANTIGEN; COPY NUMBER; POSTOPERATIVE CHEMORADIOTHERAPY; PROGNOSTIC-SIGNIFICANCE; NONOPERATIVE TREATMENT;

D O I：

10.1016/j.clcc.2015.05.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Standard treatment of patients with locally advanced rectal cancer (LARC) includes neoadjuvant chemoradiotherapy (NCRT) followed by surgery. Tumor regression after NCRT varies substantially among individuals and pathological complete response is a known prognostic factor for LARC. The identification of a predictive model for response to chemoradiotherapy would help clinicians to identify patients who would probably benefit from multimodal treatment and to perform an early assessment of individual prognosis. Carcinoembryonic antigen has proven to be a good predictor of response in several clinical trials. Other widely studied predictive models in LARC include molecular biomarkers, analyzed at various levels and by different techniques, and molecular imaging, in particular magnetic resonance imaging and positron emission tomography/computed tomography. Although none of the studied markers have been approved in clinical practice, their evaluation in larger, prospective trials and in combined predictive models could be of use to define tailored therapeutic strategies. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：227 / 238

页数：12

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