Preoperative Prediction of Pathologic Response to Neoadjuvant Chemoradiotherapy in Patients With Esophageal Cancer Using 18F-FDG PET/CT and DW-MRI: A Prospective Multicenter Study

被引：63

作者：

Borggreve, Alicia S. ^{[1
,2
]}

Goense, Lucas ^{[1
,2
]}

van Rossum, Peter S. N. ^{[1
]}

Heethuis, Sophie E. ^{[1
]}

van Hillegersberg, Richard ^{[2
]}

Lagendijk, Jan J. W. ^{[1
]}

Lam, Marnix G. E. H. ^{[3
]}

van Lier, Astrid L. H. M. W. ^{[1
]}

Mook, Stella ^{[1
]}

Ruurda, Jelle P. ^{[2
]}

van Vulpen, Marco ^{[4
]}

Voncken, Francine E. M. ^{[5
]}

Aleman, Berthe M. P. ^{[5
]}

Bartels-Rutten, Annemarieke ^{[6
]}

Ma, Jingfei ^{[7
]}

Fang, Penny ^{[8
]}

Musall, Benjamin C. ^{[7
]}

Lin, Steven H. ^{[8
]}

Meijer, Gert J. ^{[1
]}

机构：

[1] Univ Utrecht, Univ Med Ctr Utrecht, Dept Radiat Oncol, Utrecht, Netherlands

[2] Univ Utrecht, Univ Med Ctr Utrecht, Dept Surg, Utrecht, Netherlands

[3] Univ Utrecht, Univ Med Ctr Utrecht, Dept Nucl Med, Utrecht, Netherlands

[4] Proton Therapy Ctr Delft, Delft, Netherlands

[5] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands

[6] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Radiol, Amsterdam, Netherlands

[7] Univ Texas MD Anderson Canc Ctr, Dept Imaging Phys, Houston, TX 77030 USA

[8] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2020年 / 106卷 / 05期

基金：

美国国家卫生研究院;

关键词：

POSITRON-EMISSION-TOMOGRAPHY; FDG PET; THERAPY; CARCINOMA; CHEMORADIATION; SURVIVAL;

D O I：

10.1016/j.ijrobp.2019.12.038

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Accurate preoperative prediction of pathologic response to neoadjuvant chemoradiotherapy (nCRT) in patients with esophageal cancer could enable omission of esophagectomy in patients with a pathologic complete response (pCR). This study aimed to evaluate the individual and combined value of F-18-fluorodeoxyglucose positron emission tomography with integrated computed tomography (F-18-FDG PET/CT) and diffusion-weighted magnetic resonance imaging (DW-MRI) during and after nCRT to predict pathologic response in patients with esophageal cancer. Methods and Materials: In this multicenter prospective study, patients scheduled to receive nCRT followed by esophagectomy for esophageal cancer underwent (18)FFDG PET/CT and DW-MRI scanning before the start of nCRT, during nCRT, and before esophagectomy. Response to nCRT was based on histopathologic evaluation of the resection specimen. Relative changes in F-18-FDG PET/CT and DW-MRI parameters were compared between patients with pCR and non-pCR groups. Multivariable ridge regression analyses with bootstrapped c-indices were performed to evaluate the individual and combined value of F-18-FDG PET/CT and DW-MRI. Results: pCR was found in 26.1% of 69 patients. Relative changes in F-18-FDG PET/CT parameters after nCRT (Delta standardized uptake value [SUV](mean,post) P = .016, and Delta total lesion glycolysis (post) P = .024), as well as changes in DW-MRI parameters during nCRT (Delta apparent diffusion coefficient [ADC] (during) P = .008) were significantly different between pCR and non-pCR. A c-statistic of 0.84 was obtained for a model with Delta ADC(during), Delta SUVmean,post, and histology in classifying patients as pCR (versus 0.82 for Delta ADC(during) and 0.79 for Delta SUVmean, post alone). Conclusions: Changes on F-18-FDG PET/CT after nCRT and early changes on DWMRI during nCRT can help identify pCR to nCRT in esophageal cancer. Moreover, F-18-FDG PET/CT and DW-MRI might be of complementary value in the assessment of pCR. (C) 2020 Elsevier Inc. All rights reserved.

引用

页码：998 / 1009

页数：12

共 43 条

[21] Benchmarking Complications Associated With Esophagectomy [J].

Low, Donald E. ;

Kuppusamy, Madhan Kumar ;

Alderson, Derek ;

Cecconello, Ivan ;

Chang, Andrew C. ;

Darling, Gail ;

Davies, Andrew ;

D'Journo, Xavier Benoit ;

Gisbertz, Suzanne S. ;

Griffin, S. Michael ;

Hardwick, Richard ;

Hoelscher, Arnulf ;

Hofstetter, Wayne ;

Jobe, Blair ;

Kitagawa, Yuko ;

Law, Simon ;

Mariette, Christophe ;

Maynard, Nick ;

Morse, Christopher R. ;

Nafteux, Philippe ;

Pera, Manuel ;

Pramesh, C. S. ;

Puig, Sonia ;

Reynolds, John V. ;

Schroeder, Wolfgang ;

Smithers, Mark ;

Wijnhoven, B. P. L. .

ANNALS OF SURGERY, 2019, 269 (02) :291-298

[22] Assessment of response to neoadjuvant therapy in esophageal cancer: an updated systematic review of diagnostic accuracy of endoscopic ultrasonography and fluorodeoxyglucose positron emission tomography [J].

Ngamruengphong, S. ;

Sharma, V. K. ;

Nguyen, B. ;

Das, A. .

DISEASES OF THE ESOPHAGUS, 2010, 23 (03) :216-231

[23] Patients' preferences for treatment after neoadjuvant chemoradiotherapy for oesophageal cancer [J].

Noordman, B. J. ;

de Bekker-Grob, E. W. ;

Coene, P. P. L. O. ;

van der Harst, E. ;

Lagarde, S. M. ;

Shapiro, J. ;

Wijnhoven, B. P. L. ;

van Lanschot, J. J. B. .

BRITISH JOURNAL OF SURGERY, 2018, 105 (12) :1630-+

[24] Active surveillance in clinically complete responders after neoadjuvant chemoradiotherapy for esophageal or junctional cancer [J].

Noordman, B. J. ;

Wijnhoven, B. P. L. ;

Lagarde, S. M. ;

Biermann, K. ;

van der Gaast, A. ;

Spaander, M. C. W. ;

Valkema, R. ;

van Lanschot, J. J. B. .

DISEASES OF THE ESOPHAGUS, 2017, 30 (12)

[25] Detection of residual disease after neoadjuvant chemoradiotherapy for oesophageal cancer (preSANO): a prospective multicentre, diagnostic cohort study [J].

Noordman, Bo Jan ;

Spaander, Manon C. W. ;

Valkema, Roelf ;

Wijnhoven, Bas P. L. ;

Henegouwen, Mark I. van Berge ;

Shapiro, Joel ;

Biermann, Katharina ;

van der Gaast, Ate ;

van Hillegersberg, Richard ;

Hulshof, Maarten C. C. M. ;

Krishnadath, Kausilia K. ;

Lagarde, Sjoerd M. ;

Nieuwenhuijzen, Grard A. P. ;

Oostenbrug, Liekele E. ;

Siersema, Peter D. ;

Schoon, Erik J. ;

Sosef, Meindert N. ;

Steyerberg, Ewout W. ;

van Lanschot, J. Jan B. .

LANCET ONCOLOGY, 2018, 19 (07) :965-974

[26] Impact of Surgical Approach on Long-term Survival in Esophageal Adenocarcinoma Patients With or Without Neoadjuvant Chemoradiotherapy [J].

Noordman, Bo Jan ;

van Klaveren, David ;

Henegouwen, Mark I. van Berge ;

Wijnhoven, Bas P. L. ;

Gisbertz, Suzanne S. ;

Lagarde, Sjoerd M. ;

van der Gaast, Ate ;

Hulshof, Maarten C. C. M. ;

Biermann, Katharina ;

Steyerberg, Ewout W. ;

van Lanschot, J. Jan B. .

ANNALS OF SURGERY, 2018, 267 (05) :892-897

[27] How to develop a more accurate risk prediction model when there are few events [J].

Pavlou, Menelaos ;

Ambler, Gareth ;

Seaman, Shaun R. ;

Guttmann, Oliver ;

Elliott, Perry ;

King, Michael ;

Omar, Rumana Z. .

BMJ-BRITISH MEDICAL JOURNAL, 2015, 351

[28] 7th Edition of the AJCC Cancer Staging Manual: Esophagus and Esophagogastric Junction [J].

Rice, Thomas W. ;

Blackstone, Eugene H. ;

Rusch, Valerie W. .

ANNALS OF SURGICAL ONCOLOGY, 2010, 17 (07) :1721-1724

[29] Assessment of treatment response and recurrence in esophageal carcinoma based on tumor length and standardized uptake value on positron emission tomography-computed tomography [J].

Roedl, Johannes B. ;

Harisinghani, Mukesh G. ;

Colen, Rivka R. ;

Fischman, Alan J. ;

Blake, Michael A. ;

Mathisen, Douglas J. ;

Mueller, Peter R. .

ANNALS OF THORACIC SURGERY, 2008, 86 (04) :1131-1138

[30] Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial [J].

Shapiro, Joel ;

Van Lanschot, J. Jan B. ;

Hulshof, Maarten C. C. M. ;

van Hagen, Pieter ;

Henegouwen, Mark I. van Berge ;

Wijnhoven, Bas P. L. ;

van Laarhoven, Hanneke W. M. ;

Nieuwenhuijzen, Grard A. P. ;

Hospers, Geke A. P. ;

Bonenkamp, Johannes J. ;

Cuesta, Miguel A. ;

Blaisse, Reinoud J. B. ;

Busch, Olivier R. C. ;

ten Kate, Fiebo J. W. ;

Creemers, Geert-Jan M. ;

Punt, Cornelis J. A. ;

Plukker, John Th M. ;

Verheul, Henk M. W. ;

Bilgen, Ernst J. Spillenaar ;

van Dekken, Herman ;

van der Sangen, Maurice J. C. ;

Rozema, Tom ;

Biermann, Katharina ;

Beukema, Jannet C. ;

Piet, Anna H. M. ;

van Rij, Caroline M. ;

Reinders, Janny G. ;

Tilanus, Hugo W. ;

Steyerberg, Ewout W. ;

van der Gaast, Ate .

LANCET ONCOLOGY, 2015, 16 (09) :1090-1098

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