Preoperative Prediction of Pathologic Response to Neoadjuvant Chemoradiotherapy in Patients With Esophageal Cancer Using 18F-FDG PET/CT and DW-MRI: A Prospective Multicenter Study

被引：63

作者：

Borggreve, Alicia S. ^{[1
,2
]}

Goense, Lucas ^{[1
,2
]}

van Rossum, Peter S. N. ^{[1
]}

Heethuis, Sophie E. ^{[1
]}

van Hillegersberg, Richard ^{[2
]}

Lagendijk, Jan J. W. ^{[1
]}

Lam, Marnix G. E. H. ^{[3
]}

van Lier, Astrid L. H. M. W. ^{[1
]}

Mook, Stella ^{[1
]}

Ruurda, Jelle P. ^{[2
]}

van Vulpen, Marco ^{[4
]}

Voncken, Francine E. M. ^{[5
]}

Aleman, Berthe M. P. ^{[5
]}

Bartels-Rutten, Annemarieke ^{[6
]}

Ma, Jingfei ^{[7
]}

Fang, Penny ^{[8
]}

Musall, Benjamin C. ^{[7
]}

Lin, Steven H. ^{[8
]}

Meijer, Gert J. ^{[1
]}

机构：

[1] Univ Utrecht, Univ Med Ctr Utrecht, Dept Radiat Oncol, Utrecht, Netherlands

[2] Univ Utrecht, Univ Med Ctr Utrecht, Dept Surg, Utrecht, Netherlands

[3] Univ Utrecht, Univ Med Ctr Utrecht, Dept Nucl Med, Utrecht, Netherlands

[4] Proton Therapy Ctr Delft, Delft, Netherlands

[5] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands

[6] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Radiol, Amsterdam, Netherlands

[7] Univ Texas MD Anderson Canc Ctr, Dept Imaging Phys, Houston, TX 77030 USA

[8] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2020年 / 106卷 / 05期

基金：

美国国家卫生研究院;

关键词：

POSITRON-EMISSION-TOMOGRAPHY; FDG PET; THERAPY; CARCINOMA; CHEMORADIATION; SURVIVAL;

D O I：

10.1016/j.ijrobp.2019.12.038

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Accurate preoperative prediction of pathologic response to neoadjuvant chemoradiotherapy (nCRT) in patients with esophageal cancer could enable omission of esophagectomy in patients with a pathologic complete response (pCR). This study aimed to evaluate the individual and combined value of F-18-fluorodeoxyglucose positron emission tomography with integrated computed tomography (F-18-FDG PET/CT) and diffusion-weighted magnetic resonance imaging (DW-MRI) during and after nCRT to predict pathologic response in patients with esophageal cancer. Methods and Materials: In this multicenter prospective study, patients scheduled to receive nCRT followed by esophagectomy for esophageal cancer underwent (18)FFDG PET/CT and DW-MRI scanning before the start of nCRT, during nCRT, and before esophagectomy. Response to nCRT was based on histopathologic evaluation of the resection specimen. Relative changes in F-18-FDG PET/CT and DW-MRI parameters were compared between patients with pCR and non-pCR groups. Multivariable ridge regression analyses with bootstrapped c-indices were performed to evaluate the individual and combined value of F-18-FDG PET/CT and DW-MRI. Results: pCR was found in 26.1% of 69 patients. Relative changes in F-18-FDG PET/CT parameters after nCRT (Delta standardized uptake value [SUV](mean,post) P = .016, and Delta total lesion glycolysis (post) P = .024), as well as changes in DW-MRI parameters during nCRT (Delta apparent diffusion coefficient [ADC] (during) P = .008) were significantly different between pCR and non-pCR. A c-statistic of 0.84 was obtained for a model with Delta ADC(during), Delta SUVmean,post, and histology in classifying patients as pCR (versus 0.82 for Delta ADC(during) and 0.79 for Delta SUVmean, post alone). Conclusions: Changes on F-18-FDG PET/CT after nCRT and early changes on DWMRI during nCRT can help identify pCR to nCRT in esophageal cancer. Moreover, F-18-FDG PET/CT and DW-MRI might be of complementary value in the assessment of pCR. (C) 2020 Elsevier Inc. All rights reserved.

引用

页码：998 / 1009

页数：12

共 43 条

[1] Oesophageal preservation in locally advanced oesophageal cancer [J].

Ajani, Jaffer A. ;

Bhutani, Manoop S. ;

Swisher, Stephen G. .

LANCET ONCOLOGY, 2018, 19 (09) :E430-E430

[2]

Andre Jalal B, 2010, Top Magn Reson Imaging, V21, P367, DOI 10.1097/RMR.0b013e31823e65a1

[3] Apparent Diffusion Coefficient Values Measured by Diffusion-Weighted Imaging Predict Chemoradiotherapeutic Effect for Advanced Esophageal Cancer [J].

Aoyagi, Tomoyoshi ;

Shuto, Kiyohiko ;

Okazumi, Shinichi ;

Shimada, Hideaki ;

Kazama, Toshiki ;

Matsubara, Hisahiro .

DIGESTIVE SURGERY, 2011, 28 (04) :252-257

[4] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[5] Prediction of Response to Neoadjuvant Chemotherapy and Radiation Therapy with Baseline and Restaging 18F-FDG PET Imaging Biomarkers in Patients with Esophageal Cancer [J].

Beukinga, Roelof J. ;

Hulshoff, Jan Binne ;

Mul, Veronique E. M. ;

Noordzij, Walter ;

Kats-Ugurlu, Gursah ;

Slart, Riemer H. J. A. ;

Plukker, John T. M. .

RADIOLOGY, 2018, 287 (03) :983-992

[6] Preoperative image-guided identification of response to neoadjuvant chemoradiotherapy in esophageal cancer (PRIDE): a multicenter observational study [J].

Borggreve, A. S. ;

Mook, S. ;

Verheij, M. ;

Mul, V. E. M. ;

Bergman, J. J. ;

Bartels-Rutten, A. ;

ter Beek, L. C. ;

Beets-Tan, R. G. H. ;

Bennink, R. J. ;

Henegouwen, M. I. van Berge ;

Brosens, L. A. A. ;

Defize, I. L. ;

van Dieren, J. M. ;

Dijkstra, H. ;

van Hillegersberg, R. ;

Hulshof, M. C. ;

van Laarhoven, H. W. M. ;

Lam, M. G. E. H. ;

van Lier, A. L. H. M. W. ;

Muijs, C. T. ;

Nagengast, W. B. ;

Nederveen, A. J. ;

Noordzij, W. ;

Plukker, J. T. M. ;

van Rossum, P. S. N. ;

Ruurda, J. P. ;

van Sandick, J. W. ;

Weusten, B. L. A. M. ;

Voncken, F. E. M. ;

Yakar, D. ;

Meijer, G. J. .

BMC CANCER, 2018, 18

[7] Can 18F-fluorodeoxyglucose positron emission tomography predict responses to neoadjuvant therapy in oesophageal cancer patients? A meta-analysis [J].

Chen, Yu-mei ;

Pan, Xu-feng ;

Tong, Lin-jun ;

Shi, Yi-ping ;

Chen, Tao .

NUCLEAR MEDICINE COMMUNICATIONS, 2011, 32 (11) :1005-1010

[8] Posttherapy pathologic stage predicts survival in patients with esophageal carcinoma receiving preoperative chemoradiation [J].

Chirieac, LR ;

Swisher, SG ;

Ajani, JA ;

Komaki, RR ;

Correa, AM ;

Morris, JS ;

Roth, JA ;

Rashid, A ;

Hamilton, SR ;

Wu, TT .

CANCER, 2005, 103 (07) :1347-1355

[9] A systematic review and meta-analysis of prognostic biomarkers in resectable esophageal adenocarcinomas [J].

Creemers, Aafke ;

Ebbing, Eva A. ;

Pelgrim, Thomas C. ;

Lagarde, Sjoerd M. ;

van Etten-Jamaludin, Faridi S. ;

Henegouwen, Mark I. van Berge ;

Hulshof, Maarten C. C. M. ;

Krishnadath, Kausilia K. ;

Meijer, Sybren L. ;

Bijlsma, Maarten F. ;

van Oijen, Martijn G. H. ;

van Laarhoven, Hanneke W. M. .

SCIENTIFIC REPORTS, 2018, 8

[10] Apparent diffusion coefficient modifications in assessing gastro-oesophageal cancer response to neoadjuvant treatment: comparison with tumour regression grade at histology [J].

De Cobelli, Francesco ;

Giganti, Francesco ;

Orsenigo, Elena ;

Cellina, Michaela ;

Esposito, Antonio ;

Agostini, Giulia ;

Albarello, Luca ;

Mazza, Elena ;

Ambrosi, Alessandro ;

Socci, Carlo ;

Staudacher, Carlo ;

Del Maschio, Alessandro .

EUROPEAN RADIOLOGY, 2013, 23 (08) :2165-2174

← 1 2 3 4 5 →