Epigenetic control of CD8+ T cell differentiation

被引：374

作者：

Henning, Amanda N. ^{[1
,2
]}

Roychoudhuri, Rahul ^{[3
]}

Restifo, Nicholas P. ^{[1
,2
]}

机构：

[1] NCI, Ctr Cell Based Therapy, NIH, Bethesda, MD 20892 USA

[2] NCI, Surg Branch, NIH, Bldg 10, Bethesda, MD 20892 USA

[3] Babraham Inst, Lab Lymphocyte Signalling & Dev, Cambridge CB22 3AT, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2018年 / 18卷 / 05期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

DNA METHYLATION; TRANSCRIPTION FACTORS; SUPER-ENHANCERS; INTRACHROMOSOMAL INTERACTIONS; DRIVEN DIFFERENTIATION; HISTONE MODIFICATIONS; REGULATORY CIRCUITRY; LINEAGE RELATIONSHIP; CHROMATIN-STRUCTURE; PD-1; EXPRESSION;

D O I：

10.1038/nri.2017.146

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Upon stimulation, small numbers of naive CD8(+) T cells proliferate and differentiate into a variety of memory and effector cell types. CD8(+) T cells can persist for years and kill tumour cells and virally infected cells. The functional and phenotypic changes that occur during CD8(+) T cell differentiation are well characterized, but the epigenetic states that underlie these changes are incompletely understood. Here, we review the epigenetic processes that direct CD8(+) T cell differentiation and function. We focus on epigenetic modification of DNA and associated histones at genes and their regulatory elements. We also describe structural changes in chromatin organization that affect gene expression. Finally, we examine the translational potential of epigenetic interventions to improve CD8(+) T cell function in individuals with chronic infections and cancer.

引用

页码：340 / 356

页数：17

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