Rapid and efficient synthesis of [11C]ureas via the incorporation of [11C]CO2 into aliphatic and aromatic amines

被引：35

作者：

Dheere, Abdul Karim Haji ^{[1
]}

Yusuf, Nadiya ^{[1
]}

Gee, Antony ^{[1
]}

机构：

[1] Kings Coll London, Div Imaging Sci & Biomed Engn, London SE1 7EH, England

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 74期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; CARBON-DIOXIDE; MILD CONDITIONS; ONE-POT; CO2; CARBOXYLATION; MITSUNOBU; AGENTS; C-11; UREA;

D O I：

10.1039/c3cc44046j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rapid urea radiolabelling methodology has been developed. [C-11]CO2 was activated by 1,8-diazabicycloundec-7-ene (DBU) in the presence of aliphatic and aromatic amines and reacted with Mitsunobu reagents to produce asymmetric C-11 radiolabelled ureas in high radiochemical yields.

引用

页码：8193 / 8195

页数：3

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