Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3

被引:182
作者
Brenmoehl, Julia [1 ]
Hoeflich, Andreas [1 ]
机构
[1] Leibniz Inst Farm Anim FBN, Dummerstorf, Germany
关键词
Sirtuin; Mitochondrial biogenesis; PGC-1; alpha; AMPK; FoxO3; mtTFA; ACTIVATED PROTEIN-KINASE; COACTIVATOR 1-ALPHA PGC-1-ALPHA; FATTY-ACID OXIDATION; SKELETAL-MUSCLE; CALORIE RESTRICTION; TRANSCRIPTION FACTOR; METABOLIC REGULATOR; AUTOREGULATORY LOOP; MAMMALIAN SIRTUINS; LYSINE ACETYLATION;
D O I
10.1016/j.mito.2013.04.002
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In this review, we discuss the dual control of mitochondrial biogenesis and energy metabolism by silent information regulator-1 and -3 (SIRT1 and SIRT3). SIRT1 activates the peroxisome proliferator activated receptor gamma co-activator 1 alpha (PGC-1 alpha)-mediated transcription of nuclear and mitochondrial genes encoding for proteins promoting mitochondria proliferation, oxidative phosphorylation and energy production, whereas SIRT3 directly acts as an activator of proteins important for oxidative phosphorylation, tricarboxylic acid (TCA) cycle and fatty-acid oxidation and indirectly of PGC-1 alpha and AMP-activated protein kinase (AMPK). The complex network involves different cellular compartments, transcriptional activation, post-translational modification and a plethora of secondary effectors. Overall, the mode of interaction between both sirtuin family members may be considered as a prominent case of molecular job-sharing. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
引用
收藏
页码:755 / 761
页数:7
相关论文
共 99 条
  • [1] A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
    Ahn, Bong-Hyun
    Kim, Hyun-Seok
    Song, Shiwei
    Lee, In Hye
    Liu, Jie
    Vassilopoulos, Athanassios
    Deng, Chu-Xia
    Finkel, Toren
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (38) : 14447 - 14452
  • [2] SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways
    Allison, Simon J.
    Milner, Jo
    [J]. CELL CYCLE, 2007, 6 (21) : 2669 - 2677
  • [3] SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD
    Amat, Ramon
    Planavila, Anna
    Chen, Shen Liang
    Iglesias, Roser
    Giralt, Marta
    Villarroya, Francesc
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (33) : 21872 - 21880
  • [4] Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria POSSIBLE DIRECT FUNCTION IN MITOCHONDRIAL BIOGENESIS
    Aquilano, Katia
    Vigilanza, Paola
    Baldelli, Sara
    Pagliei, Beatrice
    Rotilio, Giuseppe
    Ciriolo, Maria Rosa
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (28) : 21590 - 21599
  • [5] Calorie restriction, SIRT1 and metabolism: Understanding longevity
    Bordone, L
    Guarente, L
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (04) : 298 - 305
  • [6] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    Brunet, A
    Sweeney, LB
    Sturgill, JF
    Chua, KF
    Greer, PL
    Lin, YX
    Tran, H
    Ross, SE
    Mostoslavsky, R
    Cohen, HY
    Hu, LS
    Cheng, HL
    Jedrychowski, MP
    Gygi, SP
    Sinclair, DA
    Alt, FW
    Greenberg, ME
    [J]. SCIENCE, 2004, 303 (5666) : 2011 - 2015
  • [7] Muscle-specific expression of PPARγ coactivator-1α improves exercise performance and increases peak oxygen uptake
    Calvo, Jennifer A.
    Daniels, Thomas G.
    Wang, Xiaomei
    Paul, Angelika
    Lin, Jiandie
    Spiegelman, Bruce M.
    Stevenson, Susan C.
    Rangwala, Shamina M.
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2008, 104 (05) : 1304 - 1312
  • [8] AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    Canto, Carles
    Gerhart-Hines, Zachary
    Feige, Jerome N.
    Lagouge, Marie
    Noriega, Lilia
    Milne, Jill C.
    Elliott, Peter J.
    Puigserver, Pere
    Auwerx, Johan
    [J]. NATURE, 2009, 458 (7241) : 1056 - U140
  • [9] The AMP-activated protein kinase cascade - a unifying system for energy control
    Carling, D
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 2004, 29 (01) : 18 - 24
  • [10] The AMPK-FoxO3A axis as a target for cancer treatment
    Chiacchiera, Fulvio
    Simone, Cristiano
    [J]. CELL CYCLE, 2010, 9 (06) : 1091 - 1096