In this review, we discuss the dual control of mitochondrial biogenesis and energy metabolism by silent information regulator-1 and -3 (SIRT1 and SIRT3). SIRT1 activates the peroxisome proliferator activated receptor gamma co-activator 1 alpha (PGC-1 alpha)-mediated transcription of nuclear and mitochondrial genes encoding for proteins promoting mitochondria proliferation, oxidative phosphorylation and energy production, whereas SIRT3 directly acts as an activator of proteins important for oxidative phosphorylation, tricarboxylic acid (TCA) cycle and fatty-acid oxidation and indirectly of PGC-1 alpha and AMP-activated protein kinase (AMPK). The complex network involves different cellular compartments, transcriptional activation, post-translational modification and a plethora of secondary effectors. Overall, the mode of interaction between both sirtuin family members may be considered as a prominent case of molecular job-sharing. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
机构:
Univ York, Dept Biol, Yorkshire Canc Res P53 Lab, York YO10 5DD, N Yorkshire, EnglandUniv York, Dept Biol, Yorkshire Canc Res P53 Lab, York YO10 5DD, N Yorkshire, England
Allison, Simon J.
Milner, Jo
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机构:
Univ York, Dept Biol, Yorkshire Canc Res P53 Lab, York YO10 5DD, N Yorkshire, EnglandUniv York, Dept Biol, Yorkshire Canc Res P53 Lab, York YO10 5DD, N Yorkshire, England
机构:
Univ York, Dept Biol, Yorkshire Canc Res P53 Lab, York YO10 5DD, N Yorkshire, EnglandUniv York, Dept Biol, Yorkshire Canc Res P53 Lab, York YO10 5DD, N Yorkshire, England
Allison, Simon J.
Milner, Jo
论文数: 0引用数: 0
h-index: 0
机构:
Univ York, Dept Biol, Yorkshire Canc Res P53 Lab, York YO10 5DD, N Yorkshire, EnglandUniv York, Dept Biol, Yorkshire Canc Res P53 Lab, York YO10 5DD, N Yorkshire, England