Nutrient and chemical sensing by intestinal pathogens

被引:13
作者
Hernandez-Doria, Juan D. [1 ,2 ]
Sperandio, Vanessa [1 ,2 ]
机构
[1] Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA
关键词
Enterobacteriaceae; Signals; Type-III secretion; Two-component system; ENTEROPATHOGENIC ESCHERICHIA-COLI; CARBON NUTRITION; GENETIC-LOCUS; VIRULENCE; PROTEIN; SYSTEM; SECRETION; SIGNAL; HOST; EXPRESSION;
D O I
10.1016/j.micinf.2013.06.013
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Pathogenic gut bacteria, such as those comprising the Enterobacteriaceae family, have evolved sophisticated virulence mechanisms, including nutrient and chemical sensing, to escape host defense strategies and produce disease. In this review we describe the mechanisms utilized by the enteric pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 to achieve successful colonization of its mammalian host. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:759 / 764
页数:6
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