LncRNA POU3F3 promotes proliferation and inhibits apoptosis of cancer cells in triple-negative breast cancer by inactivating caspase 9

被引：41

作者：

Yang, Jun ^{[1
]}

Meng, Xuli ^{[1
]}

Yu, Yong ^{[1
]}

Pan, Lei ^{[1
]}

Zheng, Qinghui ^{[1
]}

Lin, Wei ^{[2
]}

机构：

[1] Tongde Hosp, Dept Breast & Thyroid Surg, Hangzhou, Zhejiang, Peoples R China

[2] Peoples Hosp Quzhou City, Dept Breast & Thyroid Surg, Quzhou City, Zhejiang, Peoples R China

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2019年 / 83卷 / 06期

关键词：

Triple negative breast cancer; lncRNA POU3F3; caspase; 9; diagnosis; prognosis; ACTIVATION; IDENTIFICATION; STATISTICS;

D O I：

10.1080/09168451.2019.1588097

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been reported that lncRNA POU3F3 was upregulated in esophageal squamous-cell carcinomas, indicating its role as an oncogene in this disease. However, the mechanism of its function and its involvement in other malignancies is unknown. In the present study we found that expression levels of lncRNA POU3F3 were higher in tumor tissues than in adjacent healthy tissues of triple negative breast cancer (TNBC) patients and were significantly and inversely correlated with levels of cleaved caspase 9 only in tumor tissues. In addition, plasma levels of lncRNA POU3F3 were higher in TNBC patients than in healthy controls and were significantly and inversely correlated with levels of cleaved caspase 9 only in TNBC patients. In addition, treatment of exogenous Cleaved Caspase-9 significantly attenuated the effects of lncRNA POU3F3 overexpression on cancer cell proliferation and apoptosis. lncRNA POU3F3 may promote proliferation and inhibit apoptosis of cancer cells in triple-negative breast cancer.

引用

页码：1117 / 1123

页数：7

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