Enhancement of the Antifungal Activity of Antimicrobial Drugs by Eugenia uniflora L.

被引：14
|
作者：
Santos, Karla K. A. [1 ]
Matias, Edinardo F. F. [1 ]
Tintino, Saulo R. [1 ]
Souza, Celestina E. S. [1 ]
Braga, Maria F. B. M. [1 ]
Guedes, Glaucia M. M. [1 ]
Costa, Jose G. M. [2 ]
Menezes, Irwin R. A. [3 ]
Melo Coutinho, Henrique Douglas [1 ]
机构：
[1] Reg Univ Cariri, Lab Microbiol & Mol Biol, Crato, Brazil
[2] Reg Univ Cariri, Lab Res Nat Prod, Crato, Brazil
[3] Reg Univ Cariri, Lab Pharmacol & Med Chem, Crato, Brazil
来源：
JOURNAL OF MEDICINAL FOOD | 2013年 / 16卷 / 07期
关键词：
antifungal activity; Candida sp; citotoxicity; Eugenia uniflora; modifying activity; BRAZILIAN MEDICINAL-PLANTS; ANTIBIOTIC-ACTIVITY; CRUDE EXTRACT;
D O I：
10.1089/jmf.2012.0245
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Candidiasis is the most frequent infection by opportunistic fungi such as Candida albicans, Candida tropicalis, and Candida krusei. Ethanol extract from Eugenia uniflora was assayed, for its antifungal activity, either alone or combined with four selected chemotherapeutic antimicrobial agents, including anphotericin B, mebendazole, nistatin, and metronidazole against these strains. The obtained results indicated that the association of the extract of E. uniflora to metronidazole showed a potential antifungal activity against C. tropicalis. However, no synergistic activity against the other strains was observed, as observed when the extract was associated with the other, not enhancing their antifungal activity.
引用
收藏
页码：669 / 671
页数：3
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