Penicamedine A, a Highly Oxygenated Hexacyclic Indole Alkaloid from Penicillium camemberti

被引：12

作者：

Zhu, Hucheng ^{[1
]}

Chen, Chunmei ^{[1
]}

Wang, Jianping ^{[1
]}

Li, Xiao-Nian ^{[2
]}

Wei, Guangzheng ^{[1
]}

Guo, Yi ^{[1
]}

Yao, Guangmin ^{[1
]}

Luo, Zengwei ^{[1
]}

Zhang, Jinwen ^{[3
]}

Xue, Yongbo ^{[1
]}

Zhang, Yonghui ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2015年 / 12卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Anti-HIV activity; Cytotoxic activity; Indole alkaloids; Penicamedine A; Penicillium camemberti; X-Ray crystallography; CYCLOPIAZONIC ACID; DITERPENOIDS; POLYKETIDES; DERIVATIVES;

D O I：

10.1002/cbdv.201400412

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A highly oxygenated hexacyclic indole alkaloid, penicamedine A (1), bearing a rare furan ring, was isolated from the culture broth of Penicillium camemberti, together with two known analogs, iso--cyclopiazonic acid (2) and cyclopiazonic acid (3). The structure of 1 was elucidated by comprehensive spectroscopic analyses including NMR and HR-ESI-MS. Its absolute configuration was further confirmed unambiguously by single-crystal X-ray diffraction analysis. Compound 1 was evaluated for anti-HIV activity with p24 assays and tested for cytotoxic activities against five human cancer cell lines, including HL-60, SMMC-7721, A-549, MCF-7, SW480, and the immortalized non-cancerous human pulmonary epithelial cell line BEAS-2B by MTS method.

引用

页码：1547 / 1553

页数：7

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