Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects

被引：28

作者：

Ju, Chung ^{[1
]}

Song, Sumi ^{[2
]}

Hwang, Sunyoung ^{[1
]}

Kim, Chorong ^{[2
]}

Kim, Minkyoung ^{[2
]}

Gu, Jail ^{[2
]}

Oh, Yu-Kyoung ^{[3
]}

Lee, Kyeong ^{[4
]}

Kwon, Jinsun ^{[2
]}

Lee, Kiho ^{[5
]}

Kim, Won-Ki ^{[1
]}

Choi, Yongseok ^{[2
]}

机构：

[1] Korea Univ, Coll Med, Dept Neurosci, Seoul 136705, South Korea

[2] Korea Univ, Sch Life Sci & Biotechnol, Dept Biotechnol, Seoul 136701, South Korea

[3] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[4] Dongguk Univ Seoul, Coll Pharm, Seoul 100715, South Korea

[5] Korea Univ, Coll Pharm, Sejong City 339700, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 19期

基金：

新加坡国家研究基金会;

关键词：

Cerebral ischemia; Anti-oxidant activity; Anti-excitotoxic activity; Anti-ischemic activity; Verbenone; OXIDATIVE STRESS; ROSMARINUS-OFFICINALIS; BRAIN; MECHANISMS; NEURONS; STROKE;

D O I：

10.1016/j.bmcl.2013.07.038

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-D-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-D-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：5421 / 5425

页数：5

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