Exosomes derived from stem cells as an emerging therapeutic strategy for intervertebral disc degeneration

被引：35
作者：
Hu, Zhi-Lei [1 ]
Li, Hai-Yin [1 ]
Chang, Xian [1 ]
Li, Yue-Yang [1 ]
Liu, Chen-Hao [1 ]
Gao, Xiao-Xin [1 ]
Zhai, Yu [1 ]
Chen, Yu-Xuan [2 ]
Li, Chang-Qing [1 ]
机构：
[1] Army Mil Med Univ, Xinqiao Hosp, Dept Orthoped, Xinqiao Main St, Chongqing 400037, Peoples R China
[2] Peoples Liberat Army 990 Hosp, Ctr Traumat Orthoped, Xinyang 46400, Henan, Peoples R China
来源：
WORLD JOURNAL OF STEM CELLS | 2020年 / 12卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Exosomes; Intervertebral disc degeneration; Stem cells; MicroRNA; Regenerative medicine; Biological characteristic; IN-VITRO; BIOGENESIS; BIOLOGY;
D O I：
10.4252/wjsc.v12.i8.803
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Intervertebral disc (IVD) degenerative diseases are a common problem in the world, and they cause substantial social and economic burdens for people. The current methods for treating IVD degenerative diseases mainly include surgery and conservative treatment, which cannot fundamentally restore the normal structure of the disc. With continuous research on the mechanism of degeneration and the development of regenerative medicine, rapid progress has been made in the field of regenerative medicine regarding the use of stem cell-derived exosomes, which are active biological substances used in intercellular communication, because they show a strong effect in promoting tissue regeneration. The study of exosomes in the field of IVD degeneration has just begun, and many surprising achievements have been made. This paper mainly reviews the biological characteristics of exosomes and highlights the current status of exosomes in the field of IVD degeneration, as well as future developments regarding exosomes.
引用
收藏
页码：803 / 813
页数：11
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