Glyconanoparticles as multifunctional and multimodal carbohydrate systems

被引:250
作者
Marradi, Marco [1 ,2 ]
Chiodo, Fabrizio [1 ]
Garcia, Isabel [1 ,2 ]
Penades, Soledad [1 ,2 ]
机构
[1] CIC BiomaGUNE, Biofunct Nanomat Unit, Lab GlycoNanotechnol, San Sebastian 20009, Spain
[2] Biomed Res Networking Ctr Bioengn Biomat & Nanome, San Sebastian 20009, Spain
关键词
MAGNETIC GLYCO-NANOPARTICLES; FUNCTIONALIZED GOLD NANOPARTICLES; SPONGE MICROCIONA-PROLIFERA; IRON-OXIDE NANOPARTICLES; QUANTUM DOTS; DC-SIGN; BIOMEDICAL APPLICATIONS; COLORIMETRIC DETECTION; MOLECULAR RECOGNITION; MULTIVALENT SYSTEMS;
D O I
10.1039/c2cs35420a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The quest for the construction of multivalent carbohydrate systems, with precise geometries that are highly efficient in interacting with carbohydrate binding proteins, has been a goal of synthetic chemists since the discovery of the multivalent nature of carbohydrate-mediated interactions. However, the control of the spatial and topological requirements for these systems is still a challenge. Glyconanoparticles (GNPs) are sugar-coated gold, iron oxide or semiconductor nanoparticles with defined thiol-ending glycosides that combine the multivalent presentation of carbohydrates (glycoclusters) with the special chemico-physical properties of the nano-sized metallic core. The possibility of attaching different types of carbohydrates and other molecules (such as luminescent probes, peptides, and magnetic chelates) onto the same gold nanoparticle in a controlled way (multifunctional GNPs), as well as modifying the core in order to obtain glyconanoparticles with magnetic or fluorescence properties (multimodal GNPs) makes this multivalent glyco-scaffold suitable for carrying out studies on carbohydrate-mediated interactions and applications in molecular imaging. In this review, we focus mainly on the rational design of glyconanoparticles as scaffolds for combining different ligands and survey the most recent examples of glyconanoparticles as both multivalent carbohydrate systems and probes for molecular imaging.
引用
收藏
页码:4728 / 4745
页数:18
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