Deoxyschizandrin Suppresses DSS-Induced Ulcerative Colitis in Mice

被引:15
|
作者
Zhang, Wen-feng [1 ]
Yang, Yan [1 ]
Su, Xin [1 ]
Xu, Da-yan [1 ]
Yan, Yu-li [1 ]
Gao, Qiao [1 ]
Duan, Ming-hua [1 ]
机构
[1] Changchun Univ Chinese Med, Changchun Jingyue St,Boshuo Rd 1035, Changchun, Jilin, Peoples R China
来源
SAUDI JOURNAL OF GASTROENTEROLOGY | 2016年 / 22卷 / 06期
关键词
Apoptosis; deoxyschizandrin; inflammation; inflammatory bowel disease; ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE; FACTOR-KAPPA-B; TRADITIONAL CHINESE MEDICINE; EPITHELIAL-CELLS; SCHISANDRA; LIGNANS; APOPTOSIS; THERAPY; CONSTITUENTS; PATHOGENESIS;
D O I
10.4103/1319-3767.195552
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: Deoxyschizandrin as one of the most important component of Schisandra chinensis (Turcz.) Baill plays an immunomodulatory role in a variety of diseases, yet its role in ulcerative colitis remains to be elucidated. We aimed to investigate the role of deoxyschizandrin in DSS-induced ulcerative colitis in mice. Patients and Methods: In the present study, an inflammation model of cells was constructed to confirm the anti-inflammatory effect of deoxyschizandrin. Then a mouse model with Dextran sulfate sodium sulfate (DSS)-induced ulcerative colitis was constructed, and the effects of deoxyschizandrin on mouse colon inflammation, apoptosis, and CD4 T lymphocyte infiltration in ulcerative colitis were examined. Result: Deoxyschizandrin could improve the symptoms of ulcerative colitis, determined by hematoxylin-eosin (HE) staining and histopathological scores. Moreover, deoxyschizandrin reduced the levels of inflammatory cytokines, suppressed CD4 T cell infiltration, and effectively inhibited apoptosis in the colon of DSS-induced ulcerative colitis mice. Conclusion: In summary, deoxyschizandrin can effectively rescue the symptoms of DSS-induced ulcerative colitis in mice by inhibiting inflammation. T cell infiltration and apoptosis in the colon, suggesting that deoxyschizandrin could be a potential drug in treating ulcerative colitis.
引用
收藏
页码:448 / 455
页数:8
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